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Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes
http://hdl.handle.net/2297/31364
http://hdl.handle.net/2297/31364b4a6245c-bee9-4812-a4bd-b00a49a79c14
名前 / ファイル | ライセンス | アクション |
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ME-PR-MISU-H-34952.pdf (244.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Misu, Hirofumi
× Misu, Hirofumi× Ishikura, Kazuhide× Kurita, Seiichiro× Takeshita, Yumie× Ota, Tsuguhito× Saito, Yoshiro× Takahashi, Kazuhiko× Kaneko, Shuichi× Takamura, Toshinari |
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書誌情報 |
PLoS ONE 巻 7, 号 4, p. e34952, 発行日 2012-04-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0034952 | |||||
出版者 | ||||||
出版者 | PLoS ONE | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes. Methodology/Principal Findings: We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet. Conclusions/Significance: These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes. © 2012 Misu et al. | |||||
権利 | ||||||
権利情報 | © 2012 Misu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |