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Orexin (Hypocretin) receptor agonists and antagonists for treatment of sleep disorders: Rationale for development and current status
http://hdl.handle.net/2297/34649
http://hdl.handle.net/2297/34649b4cd2306-e3bf-4cec-b87b-466e51925418
名前 / ファイル | ライセンス | アクション |
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ME-PR-MIEDA-M-83.pdf (135.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Orexin (Hypocretin) receptor agonists and antagonists for treatment of sleep disorders: Rationale for development and current status | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mieda, Michihiro
× Mieda, Michihiro× Sakurai, Takeshi |
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書誌情報 |
CNS Drugs 巻 27, 号 2, p. 83-90, 発行日 2013-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1172-7047 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11016653 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s40263-012-0036-8 | |||||
出版者 | ||||||
出版者 | Springer International Publishing | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Orexin A and orexin B are hypothalamic neuropeptides initially identified as endogenous ligands for two orphan G-protein coupled receptors (GPCRs). They play critical roles in the maintenance of wakefulness by regulating function of monoaminergic and cholinergic neurons that are implicated in the regulation of wakefulness. Loss of orexin neurons in humans is associated with narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and cataplexy, further suggesting the particular importance of orexin in the maintenance of the wakefulness state. These findings have encouraged pharmaceutical companies to develop drugs targeting orexin receptors as novel medications of sleep disorders, such as narcolepsy and insomnia. Indeed, phase III clinical trials were completed last year of suvorexant, a non-selective (dual) antagonist for orexin receptors, for the treatment of primary insomnia, and demonstrate promising results. The New Drug Application (NDA) for suvorexant has been submitted to the US FDA. Thus, the discovery of a critical role played by the orexin system in the regulation of sleep/wakefulness has opened the door of a new era for sleep medicine. © 2013 Springer International Publishing Switzerland. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |