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Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion
https://doi.org/10.24517/00014064
https://doi.org/10.24517/00014064ec4e49ea-361f-4076-bf24-0c7d5691aafc
名前 / ファイル | ライセンス | アクション |
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CA-PR-TAKINO-T-1016.pdf (921.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00014064 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Takino, Takahisa
× Takino, Takahisa× Yoshimoto, Taisuke× Nakada, Mitsutoshi× Li, Zichen× Domoto, Takahiro× Kawashiri, Shuici× Sato, Hiroshi |
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著者別表示 |
滝野, 隆久
× 滝野, 隆久× 中田, 光俊× 堂本, 貴寛× 川尻, 秀一× 佐藤, 博 |
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書誌情報 |
Biochemical and Biophysical Research Communications 巻 450, 号 2, p. 1016-1020, 発行日 2014-07-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1090-2104 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11542044 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrc.2014.06.100 | |||||
出版者 | ||||||
出版者 | Academic Press | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Fibronectin matrix formation requires the increased cytoskeletal tension generated by cadherin adhesions, and is suppressed by membrane-type 1 matrix metalloproteinase (MT1-MMP). In a co-culture of Rat1 fibroblasts and MT1-MMP-silenced HT1080 cells, fibronectin fibrils extended from Rat1 to cell-matrix adhesions in HT1080 cells, and N-cadherin adhesions were formed between Rat1 and HT1080 cells. In control HT1080 cells contacting with Rat1 fibroblasts, cell-matrix adhesions were formed in the side away from Rat1 fibroblasts, and fibronectin assembly and N-cadherin adhesions were not formed. The role of N-cadherin adhesions in fibronectin matrix formation was studied using MT1-MMP-silenced HT1080 cells. MT1-MMP knockdown promoted fibronectin matrix assembly and N-cadherin adhesions in HT1080 cells, which was abrogated by double knockdown with either integrin β1 or fibronectin. Conversely, inhibition of N-cadherin adhesions by its knockdown or treatment with its neutralizing antibody suppressed fibronectin matrix formation in MT1-MMP-silenced cells. These results demonstrate that fibronectin assembly initiated by MT1-MMP knockdown results in increase of N-cadherin adhesions, which are prerequisite for further fibronectin matrix formation. © 2014 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |