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Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma
https://doi.org/10.24517/00014239
https://doi.org/10.24517/000142396b43e43d-d017-4325-b669-766de5b3420c
名前 / ファイル | ライセンス | アクション |
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ME-PR-MATSUMOTO-K-70779.pdf (7.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00014239 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Adachi, Eri
× Adachi, Eri× Sakai, Katsuya× Nishiuchi, Takumi× Imamura, Ryu× Sato, Hiroki× Matsumoto, Kunio |
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著者別表示 |
酒井, 克也
× 酒井, 克也× 西内, 巧× 今村, 龍× 佐藤, 拓輝× 松本, 邦夫 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学ナノ生命科学研究所 / 金沢大学がん進展制御研究所 | |||||
書誌情報 |
Oncotarget 巻 7, 号 43, p. 70779-70793, 発行日 2016-09-23 |
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DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.12221 | |||||
出版者 | ||||||
出版者 | Impact Journals | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A dynamic phenotypic change contributes to the metastatic progression and drug resistance in malignant melanoma. Nevertheless, mechanisms for a phenotypic change have remained to be addressed. Here, we show that Met receptor expression changes in a cell-autonomous manner and can distinguish phenotypical differences in growth, as well as in metastatic and drug-resistant characteristics. In metastatic melanoma, the cells are composed of Met-low and Met-high populations. Met-low populations have stem-like gene expression profiles, are resistant to chemotherapeutic agents, and have shown abundant angiogenesis and rapid tumor growth in subcutaneous inoculation. Met-high populations have a differentiated phenotype, are relatively resistant to B-RAF inhibitor, and are highly metastatic to the lungs. Met plays a definitive role in lung metastasis because the lung metastasis of Met-high cells requires Met, and treatment of mice with the Met-containing exosomes from Met-high cells facilitates lung metastasis by Met-low cells. Clonal cell fate analysis showed the hierarchical phenotypical changes from Met-low to Met-high populations. Met-low cells either showed self-renewal or changed into Met-high cells, whereas Met-high cells remained Met-high. Clonal transition from Met-low to Met-high cells accompanied changes in the gene expression profile, in tumor growth, and in metastasis that were similar to those in Met-high cells. These findings indicate that malignant melanoma has the ability to undergo phenotypic change by a cell-intrinsic/autonomous mechanism that can be characterized by Met expression. | |||||
権利 | ||||||
権利情報 | © 2017 Impact Journals | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.impactjournals.com/oncotarget/ |