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Randomized Phase II trial of paclitaxel plus valproic acid vs paclitaxel alone as second-line therapy for patients with advanced gastric cancer
http://hdl.handle.net/2297/45482
http://hdl.handle.net/2297/454824659fd81-17f3-48ac-b125-6830957f39fb
名前 / ファイル | ライセンス | アクション |
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ME-PR-FUSHIDA-S-939.pdf (142.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Randomized Phase II trial of paclitaxel plus valproic acid vs paclitaxel alone as second-line therapy for patients with advanced gastric cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fushida, Sachio
× Fushida, Sachio× Kaji, Masahide× Oyama, Katsunobu× Hirono, Yasuo× Nezuka, Hideaki× Takeda, Toshiya× Tsukada, Tomoya× Fujimoto, Daisuke× Ohyama, Shigekazu× Fujimura, Takashi× Ohta, Tetsuo |
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書誌情報 |
OncoTargets and Therapy 巻 8, p. 939-941, 発行日 2015-02-18 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1178-6930 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/OTT.S83114 | |||||
出版者 | ||||||
出版者 | Dove Medical Press Ltd. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The standard regimen of second-line chemotherapy for patients with unresectable gastric cancer has not been established. However, weekly paclitaxel (wPTX) has become the preferable second-line chemotherapy in Japan. Histone deacetylase (HDAC) inhibitors have been shown to have antiproliferative activity through cell-cycle arrest, differentiation, and apoptosis in gastric cancer cells. One HDAC inhibitor, valproic acid (VPA), also inhibits tumor growth by inducing apoptosis, and enhances the efficacy of paclitaxel in a mouse xenograft model of gastric cancer. wPTX plus VPA as a second-line chemotherapy is expected to improve survival in gastric cancer patients. A multicenter randomized Phase II study was conducted to compare the effects of wPTX plus VPA and wPTX alone. A total of 66 patients participated in this study. The primary end point of the study was overall survival, and secondary end points were progression-free survival, response rate, and assessment of peripheral neuropathy. © 2015 Fushida et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |