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Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution
http://hdl.handle.net/2297/26247
http://hdl.handle.net/2297/26247c1d538be-fad6-4a44-abb8-e929d4cf4bad
名前 / ファイル | ライセンス | アクション |
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ME-PR-KOH-E-717.pdf (6.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shin, Ho-Su
× Shin, Ho-Su× Koh, Eitetsu× Kim, Dae-Soo× Murayama, Miho× Sugimoto, Kazuhiro× Maeda, Yuji× Yoshida, Atsumi× Namiki, Mikio |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Journal of Human Genetics 巻 55, 号 11, p. 717-725, 発行日 2010-11-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1434-5161 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11206160 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/jhg.2010.94 | |||||
出版者 | ||||||
出版者 | The Japan Society of Human Genetics = 日本人類遺伝学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The male-specific region of Y chromosome (MSY) has accumulated a higher density of human endogenous retroviruses (HERVs) and related sequences when compared with other regions of the human genome. Here, we focused on one HERV family, HERV-K14C that seemed to integrate preferentially into the Y chromosome in humans. To identify every copies of HERV-K14C in the human genome, we applied computational screening to map precisely the locus of individual HERV-K14C copies. Interestingly, 29 of all 146 copies were located in Y chromosome, and these 29 copies were mostly dispersed in the palindromic region. Three distinct HERV-K14C-related transcripts were found and were exclusively expressed in human testis tissue. Based on our phylogenetic analysis of the solitary LTRs derived from HERV-K14C on the Y chromosome we suggested that these sequences were generated as pairs of identical sequences. Specifically, analysis of HERV-K14C-related sequences in the palindromic region demonstrated that the Y chromosomal amplicons existed in our common ancestors and the duplicated pairs arose after divergence of great apes approximately 8-10 million years ago. Taken together, our observation suggested that HERV-K14C-related sequences contributed to genomic diversification of Y chromosome during speciation of great ape lineage. © 2010 The Japan Society of Human Genetics All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |