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全自動ELISAシステムによるゾニサミドおよびハロペリドールの血漿中濃度測定
http://hdl.handle.net/2297/6254
http://hdl.handle.net/2297/62545160d9cc-75b8-4bdd-bf3c-73bff7c9e6a9
名前 / ファイル | ライセンス | アクション |
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PH-PR-ISHIZAKI-J-358.pdf (598.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | 全自動ELISAシステムによるゾニサミドおよびハロペリドールの血漿中濃度測定 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Determination of Zonisamide and Haloperidol in Plasma by Using a Fully Automated ELISA System | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
石崎, 純子
× 石崎, 純子× 横川, 弘一× 中島, 恵美× 古田, 壽一× 越野, 好文× 関, 秀俊× 谷口, 昂× 長谷川, 光広× 山下, 純宏× 市村, 藤雄 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学大学院自然科学研究科分子作用学 | |||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院薬剤部 | |||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学大学院医学系研究科 | |||||
書誌情報 |
病院薬学 巻 23, 号 4, p. 358-363, 発行日 1997-08-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0389-9098 | |||||
出版者 | ||||||
出版者 | 日本医療薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A fully automated enzyme immunoassay system, Omni (BIO-TEK Co.) (ELISA system), using Markit-M Excegran and Markit-M Haloperidol (Dainippon Pharmaceutical Co.) was evaluated to determine the concentrations of zonisamide (ZNS) and haloperidol (HP) in human plasma. At first, the within-run (ZNS : n=8, HP : n=10) and the between-run (4 days) precisions of ZNS and HP were examined. The coefficient of the variations in both the within-run and the between-run previsions of HP were below 5.0 and 7.00/0, respectively. In contrast, the some values of ZNS were below 6.5 and 8.40/0, respectively. A good correlation was observed between this ELISA system and HPLC (r=0.917), which was used to determine the plasma ZNS concentration. In the case of HP, a good correlation was seen between this ELISA system and the manual ELISA method (r=0.978). This method was thus used to monitor the serum levels in patients receiving ZNS or HP therapy. The relationship was observed between the daily dose (mg/kg) and the plasma concentration of the trough level for ZNS and HP, respectively (r=0.750 p<0.001, r= 0.669 p<0.001). However, the ratio of the plasma concentration of ZNS and the daily dose increased significantly with aging. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |