WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "0e93ab8f-fe91-4d23-a4f0-057fd4830829"}, "_deposit": {"created_by": 3, "id": "14837", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "14837"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00014837", "sets": ["1135"]}, "author_link": ["26589", "26587", "26586", "26369", "26588"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-02-15", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "2466", "bibliographicPageStart": "2461", "bibliographicVolumeNumber": "42", "bibliographic_titles": [{"bibliographic_title": "Chemical \u0026 pharmaceutical bulletin"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Four-step synthetic routes from 3-methyladenine (10) to 7-benzyl-N6,3-dimethyladenine (1b) and 7-benzyl-1,2-dihydro-1,3-dimethyladenine (2b), selected as models for the marine sponge alkaloids agelasimine-A (1a) and agelasimine-B (2a), respectively, have been established. The key steps involved are regioselective methylations of 7-benzyl-3-methyladenine (8) and 7-benzyl-1,2-dihydro-3-methyladenine (11). The reaction of 1b with acetic anhydride in pyridine was found to give the monocyclic imidazole derivative 29b. A similar acetylation of 2b yielded the N6-acetyl derivative 20b. When treated with boiling H2O, 20b afforded 7-benzyl-2,3-dimethylhypoxanthine (21b) and a compound inferred to be the dihydrohypoxanthine derivative 30. Probable pathways to 29b from 1b and to 21b and 30 from 20b are proposed.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本薬学会"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1248/cpb.42.2461", "subitem_relation_type_select": "DOI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00602100", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0009-2363", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujii, Tozo"}], "nameIdentifiers": [{"nameIdentifier": "26586", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Toru"}], "nameIdentifiers": [{"nameIdentifier": "26587", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60162450", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60162450"}]}, {"creatorNames": [{"creatorName": "Chikazawa, Jun"}], "nameIdentifiers": [{"nameIdentifier": "26588", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Yuko"}], "nameIdentifiers": [{"nameIdentifier": "26589", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohba, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "26369", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60115219", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60115219"}, {"nameIdentifier": "60115219", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060115219"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-OHBA-M-2461.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "PH-PR-OHBA-M-2461.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/14837/files/PH-PR-OHBA-M-2461.pdf"}, "version_id": "48dcdda7-04f4-4e52-89a9-dbc78106ca65"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "adenine 1,2-dihydro acetylation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adenine methylation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adenine trisubstituted acetylation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "agelasimine-A N(7)-benzyl analogue", "subitem_subject_scheme": "Other"}, {"subitem_subject": "agelasimine-B model", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Dimroth rearrangement 1,3-dimethyladenine", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Purines. LXV. Preparatory study for the syntheses of the marine sponge purines agelasimines-A and -B: Synthesis and acetylation of their N(7)-benzyl analogues", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Purines. LXV. Preparatory study for the syntheses of the marine sponge purines agelasimines-A and -B: Synthesis and acetylation of their N(7)-benzyl analogues"}]}, "item_type_id": "4", "owner": "3", "path": ["1135"], "permalink_uri": "http://hdl.handle.net/2297/7616", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "14837", "relation": {}, "relation_version_is_last": true, "title": ["Purines. LXV. Preparatory study for the syntheses of the marine sponge purines agelasimines-A and -B: Synthesis and acetylation of their N(7)-benzyl analogues"], "weko_shared_id": 3}
Purines. LXV. Preparatory study for the syntheses of the marine sponge purines agelasimines-A and -B: Synthesis and acetylation of their N(7)-benzyl analogues
http://hdl.handle.net/2297/7616
http://hdl.handle.net/2297/7616b6148ada-9afc-4216-9356-a63357a82980
名前 / ファイル | ライセンス | アクション |
---|---|---|
PH-PR-OHBA-M-2461.pdf (1.2 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Purines. LXV. Preparatory study for the syntheses of the marine sponge purines agelasimines-A and -B: Synthesis and acetylation of their N(7)-benzyl analogues | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fujii, Tozo
× Fujii, Tozo× Saito, Toru× Chikazawa, Jun× Nakamura, Yuko× Ohba, Masashi |
|||||
書誌情報 |
Chemical & pharmaceutical bulletin 巻 42, 号 12, p. 2461-2466, 発行日 1994-02-15 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0009-2363 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00602100 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/cpb.42.2461 | |||||
出版者 | ||||||
出版者 | 日本薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Four-step synthetic routes from 3-methyladenine (10) to 7-benzyl-N6,3-dimethyladenine (1b) and 7-benzyl-1,2-dihydro-1,3-dimethyladenine (2b), selected as models for the marine sponge alkaloids agelasimine-A (1a) and agelasimine-B (2a), respectively, have been established. The key steps involved are regioselective methylations of 7-benzyl-3-methyladenine (8) and 7-benzyl-1,2-dihydro-3-methyladenine (11). The reaction of 1b with acetic anhydride in pyridine was found to give the monocyclic imidazole derivative 29b. A similar acetylation of 2b yielded the N6-acetyl derivative 20b. When treated with boiling H2O, 20b afforded 7-benzyl-2,3-dimethylhypoxanthine (21b) and a compound inferred to be the dihydrohypoxanthine derivative 30. Probable pathways to 29b from 1b and to 21b and 30 from 20b are proposed. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |