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ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride(C-78)の生体内運命(第2報): ラットにおける代謝物
http://hdl.handle.net/2297/34392
http://hdl.handle.net/2297/343926abb2dd2-c30c-4149-9108-ffe0a1a1b0d4
名前 / ファイル | ライセンス | アクション |
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PH-PR-SHIMIZU-S-244.pdf (836.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride(C-78)の生体内運命(第2報): ラットにおける代謝物 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Metabolic Fate of ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride (C-78). II. Metabolic Products in the Rat | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
山本, 譲
× 山本, 譲× 樋口, 昭平× 藤橋, 俊明× 清水, 栄× 西出, 和憲× 上坂, 征夫 |
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書誌情報 |
藥學雜誌 巻 97, 号 3, p. 244-250, 発行日 1977-03-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-6903 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00284903 | |||||
出版者 | ||||||
出版者 | 日本薬学会 Pharmaceutical Society of Japan | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The metabolic fate of ο-chloro-α-(tert-butylaminomethyl)-benzyl alcohol hydrochloride (C-78) in the rat was studied by oral administration of 14C-C-78, and the bronchodilating activities of the metabolites were also examined. The major metabolites in the urine, bile, and feces were unchanged C-78 (I) and 4-hydroxy- (II), 3-hydroxy- (III), and 4-hydroxy-5-methoxy-C-78 (IV), and their corresponding conjugates. As the minor metabolites, ο-chlorobenzoic acid, ο-chloromandelic acid, and 1-(ο-Chlorophenyl)-1, 2-ethanediol were detected by gas chromatography. These results suggested that the major metabolic pathway of C-78 in the rat is hydroxylation of the benzene ring. Although IV had no activity, II had a stronger bronchodilating activity than C-78, and III was as effective as C-78, suggesting the participation of the metabolites in the bronchodilating action and durability of C-78. | |||||
権利 | ||||||
権利情報 | Copyright © The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110003652519/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.pharm.or.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://japanlinkcenter.org/JST.Journalarchive/yakushi1947/97.244 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/article/yakushi1947/97/3/97_3_244/_article/-char/ja/ |