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小児と成人におけるボリコナゾールの血中濃度解析の比較
https://doi.org/10.24517/00015078
https://doi.org/10.24517/00015078fd29fc04-f5b6-47ba-82bc-047527cf4733
名前 / ファイル | ライセンス | アクション |
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PH-PR-ISHIZAKI-J-213.pdf (114.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | 小児と成人におけるボリコナゾールの血中濃度解析の比較 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00015078 | |||||
ID登録タイプ | JaLC | |||||
著者 |
伊藤, さつき
× 伊藤, さつき× 石崎, 純子× 小柴, 美紀恵× 五十嵐, 康郎× 長田, 直人× 菅, 幸生× 西村, 良成× 前馬, 秀明× 小泉, 晶一× 中尾, 眞二× 横川, 弘一× 崔, 吉道× 宮本, 謙一 |
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著者別表示 |
Ito, Satsuki
× Ito, Satsuki× Ishizaki, Junko× Koshibata, Mikie× Igarashi, Yasuro× Nagata, Naoto× Suga, Yukio× Nishimura, Ryosei× Maeba, Hideaki× Koizumi, Shoichi× Nakao, Shinji× Yokogawa, Koichi× Sai, Yoshimichi× Miyamoto, Ken-ichi |
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書誌情報 |
医療薬学 巻 36, 号 4, p. 213-219, 発行日 2010-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-342X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11527197 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.5649/jjphcs.36.213 | |||||
出版者 | ||||||
出版者 | 日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was to investigate whether the trough plasma concentration of voriconazole (VRCZ) in the steady-state (Cmin) influences efficacy and safety in adult and pediatric patients. Treatment was successful in 75% of pediatric patients and 56% of adult patients,and there was no association between Cmin and efficacy.However,liver dysfunction occurred more frequently in the case that Cmin was over 4μg/mL in both adult and pediatric patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose of VRCZ than adults to achieve a similar Cmin. We concluded that the use of VRCZ at a constant dose over a long period may lead to an increase in Cmin.Therefore,careful,continuous monitoring of the Cmin of VRCZ is necessary for pediatric patients,particularly recipients of hematopoietic stem cell transplantation. | |||||
権利 | ||||||
権利情報 | Copyright © 2010 日本医療薬学会 Japanese Society of Pharmaceutical Health Care and Sciences | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/jjphcs/36/4/_contents/-char/ja/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jsphcs.jp/ |