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Nucleophilic substitution reaction in indole chemistry: A synthesis of novel 7β-substituted yohimbine and 4aα-substituted 1,2,3,4-tetrahydro-β-carboline derivatives
http://hdl.handle.net/2297/19325
http://hdl.handle.net/2297/19325922959f6-5810-4289-9f5c-42a225d84615
名前 / ファイル | ライセンス | アクション |
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PH-PR-SOMEI-M-989.pdf (264.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | Nucleophilic substitution reaction in indole chemistry: A synthesis of novel 7β-substituted yohimbine and 4aα-substituted 1,2,3,4-tetrahydro-β-carboline derivatives | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshino, Katsumasa
× Yoshino, Katsumasa× Yamada, Fumio× Somei, Masanori |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学名誉教授 | |||||
書誌情報 |
Heterocycles 巻 76, 号 2, p. 989-994, 発行日 2008-11-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-5414 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00663739 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3987/COM-08-S(N)57 | |||||
出版者 | ||||||
出版者 | Japan Institute of Heterocyclic Chemistry = 日本複素環化学研究所 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | X-Ray analyses of 1-hydroxyyohimbine derivatives clearly show the deviation of the N(1)-O bond from the indole molecular plane. This phenomenon supports our working hypothesis "bishomoallylic conjugation". The deviation is responsible for the unprecedented nucleophilic substitution reaction in 1-hydroxyindole chemistry and effected the synthesis of novel 7β-heteroarylyohimbine and 4aα-heteroaryl-1,2,3,4-tetrahydro-β-carboline derivatives from the corresponding 1-hydroxyindole derivatives. © 2008 The Japan Institute of Heterocyclic Chemistry All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |