WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "8ff75144-057a-4363-8303-b0aafb96b734"}, "_deposit": {"created_by": 3, "id": "16844", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "16844"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00016844", "sets": ["1292"]}, "author_link": ["30678"], "item_7_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-06-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "49", "bibliographicPageStart": "42", "bibliographicVolumeNumber": "120", "bibliographic_titles": [{"bibliographic_title": "金沢大学十全医学会雑誌 = Journal of the Jûzen Medical Society"}]}]}, "item_7_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recently, clinical studies have suggested that eccentric exercise can be beneficial for patellar tendinopathy. It is known that loading induces collagen synthesis in tendon, but the mechanisms responsible for mediating this effect are still unclear. We hypothesized that loading-induced expression of collagen depends on a specific contraction type. Eccentric exercise induces a more beneficial healing response than concentric exercise. Two longitudinal incisions were made in rat patellar tendons and the rats were then divided into three groups: eccentric exercise group (group E; n=35); concentric exercise group (group C; n=35); non-exercise group (group N; n=35). Each rat was taught to run downhill (eccentric) or uphill (concentric) for 14 days. Patellar tendons were collected at 1, 4, 7, 14, 21, 28 and 42 days following injury. Type I and III collagen, transforming growth factor-β-1 (TGF-β-1), and matrix metalloproteinase-13 (MMP-13) were measured by reverse transcription polymerase chain reaction. The gene expression level of type I collagen of group E was significantly greater than that of group N on day 4. The gene expression level of type III collagen of group E was significantly greater than that of group N on days 7 and 14. The gene expression level of TGF-β-1 of group E was significantly greater than that of group C and group N on days 4 and 7. The gene expression level of MMP-13 of group C and group N was significantly greater than that of group E on day 21. Eccentric exercise can more effectively induce TGF- β-1 expression compared to concentric exercise and subsequently cause high expression of type I and III collagen. In addition, our results showed that eccentric exercise also reduces MMP-13 gene expression. In conclusion, eccentric exercise can aid tendon repair.", "subitem_description_type": "Abstract"}]}, "item_7_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "[Originals][原著]平成23年5月18日受付,平成23年6月17日受理", "subitem_description_type": "Other"}]}, "item_7_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "金沢大学十全医学会 = The Juzen Medical Society Kanazawa University"}]}, "item_7_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00044397", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-7226", "subitem_source_identifier_type": "ISSN"}]}, "item_7_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yagishita, Masafumi"}], "nameIdentifiers": [{"nameIdentifier": "30678", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "AN00044397-120-2-42.pdf", "filesize": [{"value": "217.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 217900.0, "url": {"label": "AN00044397-120-2-42.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/16844/files/AN00044397-120-2-42.pdf"}, "version_id": "cbe45fa5-9dc0-4a03-8fa3-49cbae6a6ab3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "eccentric exercise", "subitem_subject_scheme": "Other"}, {"subitem_subject": "patellar tendinopathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "collagen synthesis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The effect of eccentric exercise on injured patellar tendon healing in rats: a gene expression study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The effect of eccentric exercise on injured patellar tendon healing in rats: a gene expression study"}]}, "item_type_id": "7", "owner": "3", "path": ["1292"], "permalink_uri": "http://hdl.handle.net/2297/29009", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-04"}, "publish_date": "2017-10-04", "publish_status": "0", "recid": "16844", "relation": {}, "relation_version_is_last": true, "title": ["The effect of eccentric exercise on injured patellar tendon healing in rats: a gene expression study"], "weko_shared_id": -1}
The effect of eccentric exercise on injured patellar tendon healing in rats: a gene expression study
http://hdl.handle.net/2297/29009
http://hdl.handle.net/2297/29009980c4ca9-87b0-4e67-b6ec-bbb02ad2ef79
名前 / ファイル | ライセンス | アクション |
---|---|---|
AN00044397-120-2-42.pdf (217.9 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | The effect of eccentric exercise on injured patellar tendon healing in rats: a gene expression study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | eccentric exercise | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | patellar tendinopathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | collagen synthesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yagishita, Masafumi
× Yagishita, Masafumi |
|||||
書誌情報 |
金沢大学十全医学会雑誌 = Journal of the Jûzen Medical Society 巻 120, 号 2, p. 42-49, 発行日 2011-06-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-7226 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00044397 | |||||
出版者 | ||||||
出版者 | 金沢大学十全医学会 = The Juzen Medical Society Kanazawa University | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recently, clinical studies have suggested that eccentric exercise can be beneficial for patellar tendinopathy. It is known that loading induces collagen synthesis in tendon, but the mechanisms responsible for mediating this effect are still unclear. We hypothesized that loading-induced expression of collagen depends on a specific contraction type. Eccentric exercise induces a more beneficial healing response than concentric exercise. Two longitudinal incisions were made in rat patellar tendons and the rats were then divided into three groups: eccentric exercise group (group E; n=35); concentric exercise group (group C; n=35); non-exercise group (group N; n=35). Each rat was taught to run downhill (eccentric) or uphill (concentric) for 14 days. Patellar tendons were collected at 1, 4, 7, 14, 21, 28 and 42 days following injury. Type I and III collagen, transforming growth factor-β-1 (TGF-β-1), and matrix metalloproteinase-13 (MMP-13) were measured by reverse transcription polymerase chain reaction. The gene expression level of type I collagen of group E was significantly greater than that of group N on day 4. The gene expression level of type III collagen of group E was significantly greater than that of group N on days 7 and 14. The gene expression level of TGF-β-1 of group E was significantly greater than that of group C and group N on days 4 and 7. The gene expression level of MMP-13 of group C and group N was significantly greater than that of group E on day 21. Eccentric exercise can more effectively induce TGF- β-1 expression compared to concentric exercise and subsequently cause high expression of type I and III collagen. In addition, our results showed that eccentric exercise also reduces MMP-13 gene expression. In conclusion, eccentric exercise can aid tendon repair. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | [Originals][原著]平成23年5月18日受付,平成23年6月17日受理 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |