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腹膜播種患者に対するタキサン系抗癌剤の腹膜内投与時における腹水および血漿中濃度推移
http://hdl.handle.net/2297/6883
http://hdl.handle.net/2297/688313ce9b46-ccfd-4d36-90f5-f4e28903976c
名前 / ファイル | ライセンス | アクション |
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HO-PR-MIYAMOTO-K-263.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 腹膜播種患者に対するタキサン系抗癌剤の腹膜内投与時における腹水および血漿中濃度推移 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Ascites and the Plasma Concentration-Time Courses of the Taxanes Antitumor Agents Taxanes after an Intraperitoneal Administration in Patients with Peritoneal Tumors | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
古居, 奈歩
× 古居, 奈歩× 山崎, 賢× 横川, 弘一× 伏田, 幸夫× 三輪, 晃一× 宮本, 謙一 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院薬剤部 | |||||
書誌情報 |
医療薬学 巻 9, 号 3, p. 263-269, 発行日 2003-06-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-342X | |||||
出版者 | ||||||
出版者 | 日本医療薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the disposition kinetics of taxanes, an antitumor agent after the intraperitoneal administration in nine patients with peritoneal tumors. The intraperitoneal concentrations of docetaxel or paclitaxel decreased slowly following the I.p. infusion administration of either docetaxel (60-80mg/day) or paclitaxel (120-180mg/day) over a 1-hour period in patients. There was no difference in the concentration-time courses between both drugs in each patient, and the elimination half-time was about 8hr. The area under the intraperitoneal concentration-time curve (AUC_p) of paclitaxel relative to the dose was about 3-times larger than that of docetaxel. On the other hand, the permeability of these drugs from the peritoneal cavity into the systemic circulation was extremely small. The plasma concentrations and the AUC_s of both drugs showed large individual variations among the patients. The ratios of AUC_s/AUC_p of docctaxel and paclitaxel relative to the dose were 7.1×10^<-2> and 3.8×10^<-3>, respectively. The permeability of paclitaxel was only about 1/20 that of docetaxel. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |