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Rauwolfia Alkaloidsによるビンブラスチン増感作用について
http://hdl.handle.net/2297/7051
http://hdl.handle.net/2297/7051a488139d-4f2b-4b3c-9258-a1b924089716
名前 / ファイル | ライセンス | アクション |
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HO-PR-MIYAMOTO-K-1295.pdf (536.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Rauwolfia Alkaloidsによるビンブラスチン増感作用について | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Studies on Enhancement of Sensitivity to Vinblastine by Rauwolfia Alkaloids | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
宮本, 謙一
× 宮本, 謙一× 涌沢, 伸哉× 柳岡, 利一× 越浦, 良三 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院薬剤部 | |||||
書誌情報 |
藥學雜誌 巻 104, 号 12, p. 1295-1300, 発行日 1984-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-6903 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00284903 | |||||
出版者 | ||||||
出版者 | 日本薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of six Rauwolfia alkaloids on the growth inhibitory effect of vinblastine (VBL) in rat ascites hepatoma AH66 cells was investigated. When cells were treated with VBL and each alkaloid for 30 min, reserpine, rescinnamine, syrosingopine, and ajmaline markedly potentiated the effect of VBL, but dimethylaminoethylreserplinate hydrochloride (DMAR) and yohimbine did not influence. On the other hand, in the continuous treatment for 2 d, DMAR and yohimbine also potentiated the effect of VBL. All of alkaloids increased the intracellular VBL content. Among these alkaloids, reserpine markedly suppressed the activities of Mg^<2+>ATPase and Ca^<2+>ATPase in the plasma membrane and DMAR suppressed the activities of adenosine triphosphatase (ATPase) except (Na^+-K^+) ATPase. Reserpine and DMAR did not affect the VBL binding to microtubules. Reserpine inhibited the microtubule polymerization by itself and synergistically acted with VBL on microtubules but DMAR did not affect the polymerization and the effect of VBL. From the results, it was indicated that all of Rauwolfia alkaloids suppressed the active extrusion of VBL, increased the intracellular VBL content, and potentiated the effect of VBL on AH66 cells. Moreover, it was suggested that some of alkaloids including reserppine could enhance the effect of VBL even by a short term treatment because of their synergistical interaction with VBL on microtubules. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |