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新規抗癌剤DL-1-(γ-Chloropropyl)-2-chloromethylpiperidine Hydrobromideの薬理作用
http://hdl.handle.net/2297/7048
http://hdl.handle.net/2297/704865b79eb8-3df9-4e1d-ae12-f8b310ef3e03
名前 / ファイル | ライセンス | アクション |
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HO-PR-MIYAMOTO-K-347.pdf (754.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 新規抗癌剤DL-1-(γ-Chloropropyl)-2-chloromethylpiperidine Hydrobromideの薬理作用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pharmacological Studies on DL-1-(γ-Chloropropyl)-2-chloromethylpiperidine Hydrobromide, a New Antitumor Agent | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
山田, 澄
× 山田, 澄× 越浦, 良三× 宮本, 謙一× 早苗, 富士子 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院薬剤部 | |||||
書誌情報 |
藥學雜誌 巻 100, 号 3, p. 347-354, 発行日 1980-03-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-6903 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00284903 | |||||
出版者 | ||||||
出版者 | 日本薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The pharmacological properties of DL-1-(γ-chloropropyl)-2-chloromethylpiperidine hydrobromide (CAP-2), a new nitrogen mustard type antitumor agent, were investigated in various experimental animals. The LD_<50> value by intraperitoneal single injection of CAP-2 was 60.0 mg/kg for female mice and 65.0 mg/kg for male mice 7 days after injection. Female and male received a maximum tolerated dose of 30 mg/kg and 25 mg/kg, respectively, of CAP-2 intraperitoneally once a day for 7 days. Decrease of spontaneous motalities, mild prolongation of sleeping time, hypothermia, and analgesic action were observed by intraperitoneal injection in mice of a dose of 30 mg/kg of CAP-2,but not at smaller doses. In the isolated large intestine of the guinea pig, a low concentration of CAP-2 caused relaxation and a decrease of activity which was antagonistic for acetylcholine, but not for barium chloride. Intestinal relaxation disappeared and changed to intestinal contraction by the repeated application of CAP-2 (1×10^<-4>g/ml). CAP-2 (1×10^<-4>g/ml) caused intestines relaxed by atropine to contract and increased their activity. This contraction was inhibited by paraverine. In the isolated heart of the frog, CAP-2 showed a negative inotropic action and a concentration of 1×10^<-4>g/ml inhibited the diastric standstill by acetylcholine. CAP-2 did not affect femoral vessel flow in the frog even at a concentration of 3×10^<-2>g/ml. CAP-2 tended to contract the rectus abdominis muscle of the frog. In the rabbit, CAP-2 (1-5mg/kg, i.v.) exhibited a temporary hypotensive action and weak respiratory stimulation. From these results, it was confirmed that CAP-2 has a depressant effect on the central nervous system and an anticholinergic action on the peripheria. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |