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Low-dose 123I-metaiodobenzylguanidine diagnostic scan is inferior to 131I-metaiodobenzylguanidine posttreatment scan in detection of malignant pheochromocytoma and paraganglioma
http://hdl.handle.net/2297/29298
http://hdl.handle.net/2297/2929894dda764-707b-4b83-b420-4bbe8a99b7c7
名前 / ファイル | ライセンス | アクション |
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HO-PR-KAYANO-D-941.pdf (547.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Low-dose 123I-metaiodobenzylguanidine diagnostic scan is inferior to 131I-metaiodobenzylguanidine posttreatment scan in detection of malignant pheochromocytoma and paraganglioma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kayano, Daiki
× Kayano, Daiki× Taki, Junichi× Fukuoka, Makoto× Wakabayashi, Hiroshi× Inaki, Anri× Nakamura, Ayane× Kinuya, Seigo |
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書誌情報 |
Nuclear Medicine Communications 巻 32, 号 10, p. 941-946, 発行日 2011-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0143-3636 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10624879 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/MNM.0b013e32834a4445 | |||||
出版者 | ||||||
出版者 | Lippincott, Williams & Wilkins | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVE: We assessed the lesion detectability of low-dose diagnostic 123I-metaiodobenzylguanidine (MIBG) whole-body scans obtained at 6 and 24 h compared with posttreatment 131I-MIBG whole-body scans in malignant pheochromocytoma and paraganglioma. METHODS: Scintigrams obtained in 15 patients with malignant pheochromocytoma and paraganglioma were retrospectively analyzed. Diagnostic scans were performed with 111 MBq of 123I-MIBG. Therapeutic doses of 131I-MIBG (5.55-7.40 GBq) were administrated and whole-body scans were obtained at 2-5 days after 123I-MIBG administrations. We compared the number of lesions and the lesion-to-referent count ratios at 6 and 24 h of 123I-MIBG and at 2-5 days of 131I-MIBG. RESULTS: In comparison with the 6-h images of 123I-MIBG, the 24-h images of 123I-MIBG could detect more lesions in eight patients. Posttreatment 131I-MIBG scans revealed new lesions in eight patients compared with the 24-h images of 123I- MIBG. The lesion-to-referent count ratios at 6 and 24 h of 131I-MIBG and at 3 days of 131I-MIBG were increasing at later scanning time. There were significant differences in the lesion-to-referent count ratios between 6 and 24 h of 123I-MIBG (P=0.031), 6 h of 131I-MIBG and 3 days of 123I-MIBG (P=0.020), and 24 h of 123I-MIBG and 3 days of 131I-MIBG (P=0.018). CONCLUSION: Low-dose diagnostic 123I-MIBG whole-body scan is inferior to posttreatment 131I-MIBG whole-body scan in malignant pheochromocytoma and paraganglioma. Considering the scan timing of 123I-MIBG, 6-h images might have no superiority compared with 24-h images. © 2011 Wolters Kluwer Health | Lippincott Williams &Wilkins. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |