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肝内胆管癌の増殖・繊維化におけるレニン・アンギオテンシン系非依存性アンギオテンシンII産生系の役割
http://hdl.handle.net/2297/32484
http://hdl.handle.net/2297/32484b9f1e6d3-212a-47df-9634-91786974065e
名前 / ファイル | ライセンス | アクション |
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HO-PR-OKAMOTO-K-2231.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 肝内胆管癌の増殖・繊維化におけるレニン・アンギオテンシン系非依存性アンギオテンシンII産生系の役割 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The role of renin-angiotensin system independent angiotensin II production in progression and fibrosis of intrahepatic cholangiocarcinoma | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
岡本, 浩一
× 岡本, 浩一× 田島, 秀浩× 太田, 哲生× 中沼, 伸一× 林, 泰寛× 中川原, 寿俊× 大西, 一朗× 高村, 博之× 北川, 裕久× 伏田, 幸夫× 谷, 卓× 藤村, 隆× 萱原, 正都 |
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書誌情報 |
癌と化学療法 = Gan to kagaku ryoho. Cancer & chemotherapy 巻 37, 号 12, p. 2213-2233, 発行日 2010-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-0684 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00048354 | |||||
出版者 | ||||||
出版者 | 癌と化学療法社 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Angiotensin II (Ang II) plays an important role in stromal fibrosis and tumor progression in cancer tissues. Now we investigated the role of Ang II in the cross-interaction between intrahepatic cholangiocarcinoma (ICC) cells and hepatic stellate cells (HSCs). The concentrations of Ang II in ICC tissues were significantly higher than those of hepatocellular carcinoma and normal liver. The expression of Ang II type 1 receptor (AT-1) in ICC specimens, two ICC cell lines, and HSC cell line, LI-90 was demonstrated by immunostain and Western blot. The proliferative activity of ICC cells and HSCs added Ang II dose-dependently increased and telmisartan inhibited the proliferative effects in MTT assay. HSCs added Ang II showed a higher expression of α-smooth muscle actin (α-SMA) compared with control cells. Telmisartan also inhibited the activation of HSCs added Ang II. Ang II in ICC tissues may play a pivotal role in tumor growth and stromal fibrosis and Ang II receptor blocker will be a potential therapy in cancer tissue expressing AT-1. | |||||
権利 | ||||||
権利情報 | 癌と化学療法社の許可を得て登録. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |