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This study investigated the difference in prognostic efficacy of cardiac 123I-meta-iodobenzylguanidine (MIBG) imaging between the 2 etiologies.Methods and Results:All 1,322 patients with HF were enrolled and followed up at most after 10 years. The HF patients were divided into 2 groups: an ischemic group (n=362) and non-ischemic group (n=960), and Cox proportional hazards model was used for data analysis. During 10 years of follow-up, 296 (22.4%) of 1,322 patients died; the mortality rates were 21.8% and 22.6% for the ischemic and non-ischemic groups, respectively. The ischemic group had greater prevalence of sudden death and lethal acute myocardial infarction, and the non-ischemic group had a higher rate of pump failure death. On multivariate Cox proportional hazards analysis using categorized variables, in the ischemic group, delayed heart-to-mediastinum ratio (HMR; P\u003c0.0001), age (P=0.0002) and LVEF (P=0.03) were the independent significant predictors of lethal events. In the non-ischemic group, delayed HMR (P\u003c0.0001), NYHA class (P\u003c0.0001) and age (P\u003c0.0001) were significant determinants of lethal outcome.Conclusions:Cardiac MIBG imaging has nearly identical prognostic value in both ischemic and non-ischemic HF, independent of cause of cardiac death. 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Prognostic Value of Cardiac Sympathetic Nerve Imaging Using Long-Term Follow-up Data: Ischemic vs. Non-Ischemic Heart Failure Etiology
https://doi.org/10.24517/00026953
https://doi.org/10.24517/000269532fcc3f06-b121-48ac-8afd-e34670c59d4b
名前 / ファイル | ライセンス | アクション |
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HO-PR-MATSUO-S-435.pdf (683.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-06 | |||||
タイトル | ||||||
タイトル | Prognostic Value of Cardiac Sympathetic Nerve Imaging Using Long-Term Follow-up Data: Ischemic vs. Non-Ischemic Heart Failure Etiology | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00026953 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Matsuo, Shinro
× Matsuo, Shinro× Nakajima, Kenichi× Nakata, Tomoaki |
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著者別表示 |
松尾, 信郎
× 松尾, 信郎× 中嶋, 憲一 |
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書誌情報 |
Circulation Journal 巻 80, 号 2, p. 435-441, 発行日 2016-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-9843 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11591968 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1253/circj.CJ-15-0952 | |||||
出版者 | ||||||
出版者 | 日本循環器学会 = The Japanese Circulation Society | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background:Although there are several known prognostic determinants in heart failure (HF), individual risk profiles can vary, in particular between ischemic and non-ischemic HF background. This study investigated the difference in prognostic efficacy of cardiac 123I-meta-iodobenzylguanidine (MIBG) imaging between the 2 etiologies.Methods and Results:All 1,322 patients with HF were enrolled and followed up at most after 10 years. The HF patients were divided into 2 groups: an ischemic group (n=362) and non-ischemic group (n=960), and Cox proportional hazards model was used for data analysis. During 10 years of follow-up, 296 (22.4%) of 1,322 patients died; the mortality rates were 21.8% and 22.6% for the ischemic and non-ischemic groups, respectively. The ischemic group had greater prevalence of sudden death and lethal acute myocardial infarction, and the non-ischemic group had a higher rate of pump failure death. On multivariate Cox proportional hazards analysis using categorized variables, in the ischemic group, delayed heart-to-mediastinum ratio (HMR; P<0.0001), age (P=0.0002) and LVEF (P=0.03) were the independent significant predictors of lethal events. In the non-ischemic group, delayed HMR (P<0.0001), NYHA class (P<0.0001) and age (P<0.0001) were significant determinants of lethal outcome.Conclusions:Cardiac MIBG imaging has nearly identical prognostic value in both ischemic and non-ischemic HF, independent of cause of cardiac death. (Circ J 2016; 80: 435–441) | |||||
権利 | ||||||
権利情報 | Copyright © 2016 The Japanese Circulation Society 日本循環器学会 | 許可を得て登録 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |