WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "8cae2a6d-09c8-4c3f-a8fa-5ae86f54b3a8"}, "_deposit": {"created_by": 3, "id": "26992", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "26992"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00026992", "sets": ["1763"]}, "author_link": ["44934", "62445", "22059", "48990", "45301", "48987", "975", "45732", "282", "1433", "458", "111959", "88085", "45262", "111958", "45731", "30802"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-10-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "1639", "bibliographicPageStart": "1635", "bibliographicVolumeNumber": "32", "bibliographic_titles": [{"bibliographic_title": "癌と化学療法"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yonemura, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "45262", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20167042", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20167042"}]}, {"creatorNames": [{"creatorName": "Endo, Yoshio"}], "nameIdentifiers": [{"nameIdentifier": "88085", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30211783", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30211783"}]}, {"creatorNames": [{"creatorName": "Tochiori, Shizuka"}], "nameIdentifiers": [{"nameIdentifier": "111958", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bando, Etsurou"}], "nameIdentifiers": [{"nameIdentifier": "111959", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Taiichi"}], "nameIdentifiers": [{"nameIdentifier": "62445", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "44934", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90409384", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90409384"}]}, {"creatorNames": [{"creatorName": "Miyamoto, Ken-ichi"}], "nameIdentifiers": [{"nameIdentifier": "22059", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30100514", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030100514"}]}, {"creatorNames": [{"creatorName": "Tanaka, Motohiro"}], "nameIdentifiers": [{"nameIdentifier": "48990", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60197481", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60197481"}]}, {"creatorNames": [{"creatorName": "Sasaki, Takuma"}], "nameIdentifiers": [{"nameIdentifier": "48987", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90109976", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90109976"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In vitro chemosensitivity test using a collagen-gel method was done on 165 primary gastric cancers. All of 5-FU, CBDCA, CDDP and docetaxel showed a high sensitivity. The effects of per oral (po) administration of TS-1, a combination of po TS-1 and intraperitoneal (ip) administration of CDDP, ip 5-FU and ip docetaxel, were evaluated in athymic mice bearing peritoneal dissemination of a gastric cancer cell line (MKN-45-P that shows a high rate of metastasis to the peritoneal cavity of nude mice). Nude mice were inoculated by ip with 10(7) MKN-45-P cells. No survival benefit was obtained after po administration of TS-1 (12 mg/kg) alone or ip CDDP alone. However, a combination of po TS-1 (8 mg/kg x 10 days, from day 3) and ip CDDP (3.5 mg/kg, day 6 and 13) showed a significant survival improvement than that of po TS-1 or ip CDDP treatment alone. ip administration of 30 mg/kg (3 times/week x 3 weeks) or 15 mg/kg (6 times/week x 3 weeks) of 5-FU significantly improved the survival of mice bearing MKN-45-P. 5-FU concentration of ascites after ip administration of 30 mg/kg of 5-FU was 600-fold higher than po administration of 12 mg/kg of TS-1 at peak level. ip injections of docetaxel of 8 mg/kg, and 2 mg/kg improved the survival of 4 and 1 mice, respectively, and they were tumor-free on day 90. Survival of mice treated with ip injection of CBDCA (100 mg/kg, on day 3, or 50 mg/ kg on day 3 and 10) was significantly better than the control group. These results suggest the potential of po TS-1 + ip CDDP, ip 5-FU, ip docetaxel and ip CBDCA administration for the treatment of peritoneal dissemination of gastric cancer.コラーゲンゲル法により原発胃癌の薬剤感受性を調べたところ, CBDCA, CDDP, 5-FU, docetaxel(DOC)が高い感受性を示した. 胃癌高度腹膜転移株MKN-45-PをTS-1(12mg/kg)で治療した群では, 治療開始日に関係なく対照群の生存率と差がなかった. 5-FU 15mg/kg ip, 18回, 30mg/kg ip, 9回投与群ではTS-1 12mg/kg po(計20回)や対照群に比べ有意に生存率がよかった. 5-FU 30mg/kg ip投与群の注入液の5-FU濃度は600μg/mlと高値を示した. TS-1 12mg/kg投与60分での腹水中5-FU, CDHP濃度は927±558ng/ml, 1,483±719ng/mlであった. CDDP3.5mg ip投与(6, 13日)群, TS-1単独群, 対照群ではMST36, 28, 32日で差を認めなかった. しかし, CDDP+TS-1(8mg/kg)群ではMST50日で有意に他の3群より生存率が良好であった. DOC8mg/kg, 2mg/kg ip投与群ではMST90, 63日で, それぞれ4匹, 1匹は腹膜播種が消失していた. DOC8mg/kg ip投与後は8時間後も腹水中DOC濃度(4.58±0.28μg/ml)は高い濃度を維持していたが, iv投与では腹水中濃度はip投与後に比べ1/100の値であった. また, 腹膜播種組織内のDoc濃度はip投与8時間ではiv投与後に比べ有意に高い値(4.65±1.33μg/gr)を示した. CBDCA50mg/kg(day3, 7ip)100mg/kg(day3, ip)投与群では有意に対照群より生存率が良好であった. MSTは対照群26.3日, 100mg/kg群37.7日, 50mg/kg群40.3日であった. しかし, 体重減少を認めた例はなかった. 以上より胃癌高度腹膜転移株MKN-45-Pによる腹膜播種モデルにおいて, 5-Fu ip, Ts-1 po+CDDP ip, Doc ip, CBDCA ip療法は有効であり, 臨床への応用が期待される.", "subitem_description_type": "Abstract"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00026979", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "癌と化学療法社"}]}, "item_4_relation_13": {"attribute_name": "PMID", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "16315893", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ccpgan.com/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ccpgan.com/page/19", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2005 癌と化学療法社"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12405504", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-0684", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "米村, 豊"}], "nameIdentifiers": [{"nameIdentifier": "45301", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20167042", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020167042"}]}, {"creatorNames": [{"creatorName": "遠藤, 良夫"}], "nameIdentifiers": [{"nameIdentifier": "282", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30211783", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30211783"}, {"nameIdentifier": "30211783", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30211783"}, {"nameIdentifier": "30211783", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030211783"}]}, {"creatorNames": [{"creatorName": "栃折, 静"}], "nameIdentifiers": [{"nameIdentifier": "45731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "坂東, 悦郎"}], "nameIdentifiers": [{"nameIdentifier": "1433", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70399591", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=70399591"}, {"nameIdentifier": "70399591", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070399591"}]}, {"creatorNames": [{"creatorName": "川村, 泰一"}], "nameIdentifiers": [{"nameIdentifier": "975", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20283145", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20283145"}, {"nameIdentifier": "20283145", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020283145"}]}, {"creatorNames": [{"creatorName": "嶋田, 努"}], "nameIdentifiers": [{"nameIdentifier": "458", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90409384", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90409384"}, {"nameIdentifier": "90409384", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090409384"}]}, {"creatorNames": [{"creatorName": "宮本, 謙一"}], "nameIdentifiers": [{"nameIdentifier": "22059", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30100514", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030100514"}]}, {"creatorNames": [{"creatorName": "田中, 基弘"}], "nameIdentifiers": [{"nameIdentifier": "45732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐々木, 琢磨"}], "nameIdentifiers": [{"nameIdentifier": "30802", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90109976", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90109976"}, {"nameIdentifier": "90109976", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090109976"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-SHIMADA-T-1635.pdf", "filesize": [{"value": "3.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 3500000.0, "url": {"label": "PH-PR-SHIMADA-T-1635.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/26992/files/PH-PR-SHIMADA-T-1635.pdf"}, "version_id": "967e5167-77fa-449f-822d-9d0b7ef36df3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Gastric cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Peritoneal dissemination", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TS-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Docetaxel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Intraperitoneal", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chemotherapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "実験的胃癌腹膜播種に対する腹腔内化学療法の効果", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "実験的胃癌腹膜播種に対する腹腔内化学療法の効果"}, {"subitem_title": "Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer", "subitem_title_language": "en"}]}, "item_type_id": "4", "owner": "3", "path": ["1763"], "permalink_uri": "https://doi.org/10.24517/00026979", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "26992", "relation": {}, "relation_version_is_last": true, "title": ["実験的胃癌腹膜播種に対する腹腔内化学療法の効果"], "weko_shared_id": 3}
実験的胃癌腹膜播種に対する腹腔内化学療法の効果
https://doi.org/10.24517/00026979
https://doi.org/10.24517/0002697956e9170f-03bd-4834-a345-f9590bdc2f9d
名前 / ファイル | ライセンス | アクション |
---|---|---|
PH-PR-SHIMADA-T-1635.pdf (3.5 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 実験的胃癌腹膜播種に対する腹腔内化学療法の効果 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00026979 | |||||
ID登録タイプ | JaLC | |||||
著者 |
米村, 豊
× 米村, 豊× 遠藤, 良夫× 栃折, 静× 坂東, 悦郎× 川村, 泰一× 嶋田, 努× 宮本, 謙一× 田中, 基弘× 佐々木, 琢磨 |
|||||
著者別表示 |
Yonemura, Yutaka
× Yonemura, Yutaka× Endo, Yoshio× Tochiori, Shizuka× Bando, Etsurou× Kawamura, Taiichi× Shimada, Tsutomu× Miyamoto, Ken-ichi× Tanaka, Motohiro× Sasaki, Takuma |
|||||
書誌情報 |
癌と化学療法 巻 32, 号 11, p. 1635-1639, 発行日 2005-10-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-0684 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12405504 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16315893 | |||||
出版者 | ||||||
出版者 | 癌と化学療法社 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In vitro chemosensitivity test using a collagen-gel method was done on 165 primary gastric cancers. All of 5-FU, CBDCA, CDDP and docetaxel showed a high sensitivity. The effects of per oral (po) administration of TS-1, a combination of po TS-1 and intraperitoneal (ip) administration of CDDP, ip 5-FU and ip docetaxel, were evaluated in athymic mice bearing peritoneal dissemination of a gastric cancer cell line (MKN-45-P that shows a high rate of metastasis to the peritoneal cavity of nude mice). Nude mice were inoculated by ip with 10(7) MKN-45-P cells. No survival benefit was obtained after po administration of TS-1 (12 mg/kg) alone or ip CDDP alone. However, a combination of po TS-1 (8 mg/kg x 10 days, from day 3) and ip CDDP (3.5 mg/kg, day 6 and 13) showed a significant survival improvement than that of po TS-1 or ip CDDP treatment alone. ip administration of 30 mg/kg (3 times/week x 3 weeks) or 15 mg/kg (6 times/week x 3 weeks) of 5-FU significantly improved the survival of mice bearing MKN-45-P. 5-FU concentration of ascites after ip administration of 30 mg/kg of 5-FU was 600-fold higher than po administration of 12 mg/kg of TS-1 at peak level. ip injections of docetaxel of 8 mg/kg, and 2 mg/kg improved the survival of 4 and 1 mice, respectively, and they were tumor-free on day 90. Survival of mice treated with ip injection of CBDCA (100 mg/kg, on day 3, or 50 mg/ kg on day 3 and 10) was significantly better than the control group. These results suggest the potential of po TS-1 + ip CDDP, ip 5-FU, ip docetaxel and ip CBDCA administration for the treatment of peritoneal dissemination of gastric cancer.コラーゲンゲル法により原発胃癌の薬剤感受性を調べたところ, CBDCA, CDDP, 5-FU, docetaxel(DOC)が高い感受性を示した. 胃癌高度腹膜転移株MKN-45-PをTS-1(12mg/kg)で治療した群では, 治療開始日に関係なく対照群の生存率と差がなかった. 5-FU 15mg/kg ip, 18回, 30mg/kg ip, 9回投与群ではTS-1 12mg/kg po(計20回)や対照群に比べ有意に生存率がよかった. 5-FU 30mg/kg ip投与群の注入液の5-FU濃度は600μg/mlと高値を示した. TS-1 12mg/kg投与60分での腹水中5-FU, CDHP濃度は927±558ng/ml, 1,483±719ng/mlであった. CDDP3.5mg ip投与(6, 13日)群, TS-1単独群, 対照群ではMST36, 28, 32日で差を認めなかった. しかし, CDDP+TS-1(8mg/kg)群ではMST50日で有意に他の3群より生存率が良好であった. DOC8mg/kg, 2mg/kg ip投与群ではMST90, 63日で, それぞれ4匹, 1匹は腹膜播種が消失していた. DOC8mg/kg ip投与後は8時間後も腹水中DOC濃度(4.58±0.28μg/ml)は高い濃度を維持していたが, iv投与では腹水中濃度はip投与後に比べ1/100の値であった. また, 腹膜播種組織内のDoc濃度はip投与8時間ではiv投与後に比べ有意に高い値(4.65±1.33μg/gr)を示した. CBDCA50mg/kg(day3, 7ip)100mg/kg(day3, ip)投与群では有意に対照群より生存率が良好であった. MSTは対照群26.3日, 100mg/kg群37.7日, 50mg/kg群40.3日であった. しかし, 体重減少を認めた例はなかった. 以上より胃癌高度腹膜転移株MKN-45-Pによる腹膜播種モデルにおいて, 5-Fu ip, Ts-1 po+CDDP ip, Doc ip, CBDCA ip療法は有効であり, 臨床への応用が期待される. | |||||
権利 | ||||||
権利情報 | Copyright © 2005 癌と化学療法社 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ccpgan.com/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ccpgan.com/page/19 |