WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "3362fc51-7207-4c88-b7ed-b8e6ed9ed62c"}, "_deposit": {"created_by": 3, "id": "26994", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "26994"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00026994", "sets": ["1763"]}, "author_link": ["1247", "45741", "45743", "458", "45742", "21766", "1355", "45747", "45744", "45746", "45745"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "484590", "bibliographicVolumeNumber": "2011", "bibliographic_titles": [{"bibliographic_title": "Evidence-based Complementary and Alternative Medicine"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The extracts of Salacia reticulata (Salacia extract), a plant that has been used for the treatment of early diabetes, rheumatism and gonorrhea in Ayurveda, have been shown to have an anti-obesity effect and suppress hyperglycemia. In this study, the effects of Salacia extract on various symptoms of metabolic disorder were investigated and compared using these TSOD mice and non-obese TSNO mice. Body weight, food intake, plasma biochemistry, visceral and subcutaneous fat (X-ray and CT), glucose tolerance, blood pressure and pain tolerance were measured, and histopathological examination of the liver was carried out. A significant dose-dependent decline in the gain in body weight, accumulation of visceral and subcutaneous fat and an improvement of abnormal glucose tolerance, hypertension and peripheral neuropathy were noticed in TSOD mice. In addition, hepatocellular swelling, fatty degeneration of hepatocytes, inflammatory cell infiltration and single-cell necrosis were observed on histopathological examination of the liver in TSOD mice. Salacia extract markedly improved these symptoms upon treatment. Based on the above results, it is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome. © 2011 Tomoko Akase et al.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Hindawi Publishing Corporation"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1093/ecam/nep052", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_13": {"attribute_name": "PMID", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "19505975", "subitem_relation_type_select": "PMID"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2011 Tomoko Akase et al. This is an open access article distributed under the Creative Commons Attribution License,"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11968793", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1741-427X", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Akase, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "1247", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50276630", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50276630"}, {"nameIdentifier": "50276630", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050276630"}]}, {"creatorNames": [{"creatorName": "Shimada, Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "458", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90409384", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90409384"}, {"nameIdentifier": "90409384", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090409384"}]}, {"creatorNames": [{"creatorName": "Harasawa, Yukiko"}], "nameIdentifiers": [{"nameIdentifier": "45741", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akase, Tomohide"}], "nameIdentifiers": [{"nameIdentifier": "45742", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeya, Yukinobu"}], "nameIdentifiers": [{"nameIdentifier": "45743", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagai, Eiichi"}], "nameIdentifiers": [{"nameIdentifier": "45744", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iizuka, Seiichi"}], "nameIdentifiers": [{"nameIdentifier": "45745", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagami, Gojiro"}], "nameIdentifiers": [{"nameIdentifier": "45746", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iizaka, Shinji"}], "nameIdentifiers": [{"nameIdentifier": "45747", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sanada, Hiromi"}], "nameIdentifiers": [{"nameIdentifier": "21766", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50143920", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50143920"}, {"nameIdentifier": "50143920", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050143920"}]}, {"creatorNames": [{"creatorName": "Aburada, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "1355", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60409381", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60409381"}, {"nameIdentifier": "60409381", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060409381"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-SHIMADA-T-484590.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "PH-PR-SHIMADA-T-484590.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/26994/files/PH-PR-SHIMADA-T-484590.pdf"}, "version_id": "e3502e4a-06b6-4693-a28b-4d2fa22415e0"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice"}]}, "item_type_id": "4", "owner": "3", "path": ["1763"], "permalink_uri": "http://hdl.handle.net/2297/39147", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "26994", "relation": {}, "relation_version_is_last": true, "title": ["Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice"], "weko_shared_id": -1}
Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice
http://hdl.handle.net/2297/39147
http://hdl.handle.net/2297/39147b345b149-91e5-49a4-9f3c-9fa8ded971d5
名前 / ファイル | ライセンス | アクション |
---|---|---|
PH-PR-SHIMADA-T-484590.pdf (2.2 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Akase, Tomoko
× Akase, Tomoko× Shimada, Tsutomu× Harasawa, Yukiko× Akase, Tomohide× Ikeya, Yukinobu× Nagai, Eiichi× Iizuka, Seiichi× Nakagami, Gojiro× Iizaka, Shinji× Sanada, Hiromi× Aburada, Masaki |
|||||
書誌情報 |
Evidence-based Complementary and Alternative Medicine 巻 2011, p. 484590, 発行日 2011-01-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1741-427X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11968793 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/ecam/nep052 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19505975 | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The extracts of Salacia reticulata (Salacia extract), a plant that has been used for the treatment of early diabetes, rheumatism and gonorrhea in Ayurveda, have been shown to have an anti-obesity effect and suppress hyperglycemia. In this study, the effects of Salacia extract on various symptoms of metabolic disorder were investigated and compared using these TSOD mice and non-obese TSNO mice. Body weight, food intake, plasma biochemistry, visceral and subcutaneous fat (X-ray and CT), glucose tolerance, blood pressure and pain tolerance were measured, and histopathological examination of the liver was carried out. A significant dose-dependent decline in the gain in body weight, accumulation of visceral and subcutaneous fat and an improvement of abnormal glucose tolerance, hypertension and peripheral neuropathy were noticed in TSOD mice. In addition, hepatocellular swelling, fatty degeneration of hepatocytes, inflammatory cell infiltration and single-cell necrosis were observed on histopathological examination of the liver in TSOD mice. Salacia extract markedly improved these symptoms upon treatment. Based on the above results, it is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome. © 2011 Tomoko Akase et al. | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Tomoko Akase et al. This is an open access article distributed under the Creative Commons Attribution License, | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |