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Altered dendritic spine plasticity in cocaine-withdrawn rats
http://hdl.handle.net/2297/17586
http://hdl.handle.net/2297/175862213938d-3d97-4a39-83f9-e012fad6271a
名前 / ファイル | ライセンス | アクション |
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HO-PR-TODA-S-2876.pdf (541.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Altered dendritic spine plasticity in cocaine-withdrawn rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shen, Hao-wei
× Shen, Hao-wei× Toda, Shigenobu× Moussawi, Khaled× Bouknight, Ashley× Zahm, Daniel S.× Kalivas, Peter W. |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院神経科精神科 | |||||
書誌情報 |
Journal of Neuroscience 巻 29, 号 9, p. 2876-2884, 発行日 2009-03-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0270-6474 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10620404 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1523/JNEUROSCI.5638-08.2009 | |||||
出版者 | ||||||
出版者 | Society for Neuroscience | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chronic cocaine treatment is associated with changes in dendritic spines in the nucleus accumbens, but it is unknown whether this neuroplasticity alters the effect of a subsequent cocaine injection on spine morphology and protein content. Three weeks after daily cocaine or saline administration, neurons in the accumbens were filled with the lipophilic dye, DiI. Although daily cocaine pretreatment did not alter spine density compared with daily saline, there was a shift from smaller to larger diameter spines. During the first 2 h after an acute cocaine challenge, a bidirectional change in spine head diameter and increase in spine density was measured in daily cocainepretreated animals. In contrast, no change in spine diameter or density was elicited by a cocaine challenge in daily saline animals during the first 2 h after injection. However, spine density was elevated at 6 h after a cocaine challenge in daily saline-pretreated animals. The time-dependent profile of proteins in the postsynaptic density subfraction elicited by a cocaine challenge in daily cocaine-pretreated subjects indicated that the changes in spine diameter and density were associated with a deteriorating actin cytoskeleton and a reduction in glutamate signaling-related proteins. Correspondingly, the amplitude of field potentials in accumbens evoked by stimulating prefrontal cortex was reduced for up to 6 h after acute cocaine in daily cocaine-withdrawn animals. These data indicate that daily cocaine pretreatment dysregulates dendritic spine plasticity elicited by a subsequent cocaine injection. Copyright © 2009 Society for Neuro science. | |||||
権利 | ||||||
権利情報 | Copyright © 2009 Society for Neuro science | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jneurosci.org/cgi/content/abstract/29/9/2876 |