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Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-Fas ligand antibody therapy
https://doi.org/10.24517/00027372
https://doi.org/10.24517/000273725c973a0e-137c-4c12-9414-0375e1ca7229
名前 / ファイル | ライセンス | アクション |
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CA-PR-SUDA-T-1105.pdf (249.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-Fas ligand antibody therapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00027372 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Nakamoto, Yasunari
× Nakamoto, Yasunari× Kaneko, Shuichi× Fan, Hong× Momoi, Takashi× Tsutsui, Hiroko× Nakanishi, Kenji× Kobayashi, Kenichi× Suda, Takashi |
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著者別表示 |
中本, 安成
× 中本, 安成× 金子, 周一× 須田, 貴司 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん研究所がん病態制御 | |||||
書誌情報 |
Journal of Experimental Medicine 巻 196, 号 8, p. 1105-1111, 発行日 2002-10-21 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-1007 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00697559 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1084/jem.20020633 | |||||
出版者 | ||||||
出版者 | Rockefeller University Press | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A persistent immune response to hepatitis viruses is a well-recognized risk factor for hepatocellular carcinoma. However, the molecular and cellular basis for the procarcinogenic potential of the immune response is not well defined. Here, using a unique animal model of chronic hepatitis that induces hepatocellular carcinogenesis, we demonstrate that neutralization of the activity of Fas ligand prevented hepatocyte apoptosis, proliferation, liver inflammation, and the eventual development of hepatocellular carcinoma. The results indicate that Fas ligand is involved not only in direct hepatocyte killing but also in the process of inflammation and hepatocellular carcinogenesis in chronic hepatitis. This is the first demonstration that amelioration of chronic inflammation by some treatment actually caused reduction of cancer development. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |