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Molecular mechanisms of therapeutic effects of Saiko-keishi-to on spontaneous chronic pancreatitis in the WBN/Kob rat
http://hdl.handle.net/2297/23598
http://hdl.handle.net/2297/235982f334d9e-db25-4a28-a404-35ed8afbb340
名前 / ファイル | ライセンス | アクション |
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CA-PR-MOTOO-Y-143.pdf (831.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Molecular mechanisms of therapeutic effects of Saiko-keishi-to on spontaneous chronic pancreatitis in the WBN/Kob rat | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Motoo, Yoshiharu
× Motoo, Yoshiharu× Xie, Min-Jue× Su, Shi-Bing× Sawabu, Norio |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん研究所 | |||||
書誌情報 |
Journal of traditional medicines = 和漢医薬学雑誌 巻 20, 号 4, p. 143-149, 発行日 2003-08-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-1447 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
出版者 | ||||||
出版者 | Medical and Pharmaceutical Society for WAKAN-YAKU = 和漢医薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 柴胡桂枝湯(TJ-10)は慢性膵炎の経口治療薬として臨床的に使用されてきた。本総説ではWBN/Kobラットにおける自然発症慢性膵炎に対するTJ-10の治療効果の分子機構について我々の実験結果を中心に述べた。 RT-PCR解析によるpancreatitis-associated protein(PAP)やサイトカイン(TNF-α,IL-6など)の発現抑制からTJ-10の抗炎症作用が示唆された。アザン染色からみた膵線維化改善やTGF-β,α平滑筋アクチン,III型コラーゲン,ファイブロネクチンなどの線維化関連因子の発現抑制によりTJ-10の抗線維化作用を確認した。 TUNEL法やFas,Fasリガンドなどのアポトーシス関連因子の発現抑制より膵腺房細胞に対するTJ-10の抗アポトーシス作用が示唆された。最後にSODの発現増加とiNOS発現抑制によりTJ-10の抗酸化作用を確認した。以上より,TJ-10は抗炎症・抗線維化・抗アポトーシス・抗酸化の4つの作用機序により慢性膵炎に有効であると考えられた。Saiko-keishi-to (TJ-10) has been clinically used as an oral therapeutic drug for chronic pancreatitis. In this review, we present our data on molecular action mechanisms of TJ-10 on spontaneous chronic pancreatitis in the WBN/Kob rats. Anti-inflammatory effects of TJ-10 were suggested by the suppression of the gene expressions of pancreatitis-associated protein (PAP), cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 by reverse transcription-polymerase chain reaction (RT-PCR) analysis. Anti-fibrotic effects were confirmed by the observations on the amelioration of pancreatic fibrosis assessed with AZAN staining and the analysis of expressions of fibrosis-related factors such as transforming growth factor (TGF)-β, α-smooth muscle actin, type III collagen and fibronectin. Anti-apoptotic effect was examined with the TUNEL method and the analysis of apoptosis-related factors such as Fas and Fas ligand. Anti-oxidant effect was suggested by the findings of TJ-10-induced enhancement of the expression of superoxide dismutase and the suppression of the expression of inducible nitric oxide synthase. These results suggest that TJ-10 is effective for chronic pancreatitis by the major four action mechanisms: anti-inflammatory, anti-fibrotic, anti-apoptotic, and anti-oxidant effects. | |||||
権利 | ||||||
権利情報 | 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110001846597/en/ |