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Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by Pristane and Abelson virus
http://hdl.handle.net/2297/29242
http://hdl.handle.net/2297/292428789b89d-9198-4d6e-adc4-85f035690d9b
名前 / ファイル | ライセンス | アクション |
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CA-PR-OHNO-S-1762.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by Pristane and Abelson virus | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ohno, Shinsuke
× Ohno, Shinsuke× Migita, Shunsuke× Wiener, Francis× Babonits, M.× Klein, G.× Mushinski, J. F.× Potter, M. |
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書誌情報 |
Journal of Experimental Medicine 巻 159, 号 6, p. 1762-1777, 発行日 1984-06-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-1007 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00697559 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1084/jem.159.6.1762 | |||||
出版者 | ||||||
出版者 | Rockefeller University Press | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Plasmacytomas with short latent periods can be induced in BALB/c mice by a single intraperitoneal (i.p.) injection of 0.5 ml pristane followed 20-40 d later by an injection of Abelson virus. The karyotypes of 18 such tumors were determined; 10 of these had rcpt 12;15, 5 had rcpt 6;15 and 3 had no translocations, but two of these have been shown to have interstitial deletions of chromosome 15. The specific breakpoints were the same as described in pristane-induced plasmacytomas, i.e., at 15D2/3, 6C2, and 12F2. Near diploid karyotypes and trisomy of chromosome 11 were frequently seen. All of the Abelson-plus-pristane-induced plasmacytomas (ABPC) were studied as transplanted tumors, contained integrated v-abl sequences, and actively transcribed v-abl mRNA. All but one of these tumors contained abundant myc RNA transcripts. The shortness of the latent periods of the ABPC suggests that the rcpt 12;15 and rcpt 6;15 occur soon after pristane administration and are present at the time Abelson virus is introduced. In this form of plasmacytomagenesis, activated v-abl genes appear to bypass other genetic changes that require a much longer period of time in pristane plasmacytomagenesis. Nonetheless, the consistent finding of chromosome-15 alterations and abundant myc expression in these plasmacytomas emphasize the apparent need for multiple events even in the genesis of some tumors induced by rapid transforming viruses. | |||||
権利 | ||||||
権利情報 | © 1984 Rockefeller University Press | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://jem.rupress.org/content/159/6/1762 |