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鶏卵法による温熱と抗癌剤併用効果の検討
https://doi.org/10.24517/00027450
https://doi.org/10.24517/0002745061d6a5e2-fb3f-4c2b-9e1d-05341d659a0c
名前 / ファイル | ライセンス | アクション |
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CA-PR-ENDO-Y-17.pdf (3.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 鶏卵法による温熱と抗癌剤併用効果の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Responses of tumor cell lines and surgical specimens transplanted onto chorioallantoic membrane of chick embryo to anticancer agents in combination with/without hyperthermia | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00027450 | |||||
ID登録タイプ | JaLC | |||||
著者 |
打林, 忠雄
× 打林, 忠雄× 江川, 雅之× 浅利, 豊紀× 中嶋, 和喜× 久住, 治男× 遠藤, 良夫× 田中, 基裕× 佐々木, 琢磨 |
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著者別表示 |
Uchimayashi, Tadao
× Uchimayashi, Tadao× Egawa, Masayuki× Asari, Toyoki× Nakajima, Kazuyoshi× Hisazumi, Haruo× Endo, Yoshio× Tanaka, Motohiro× Sasaki, Takuma |
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書誌情報 |
日本泌尿器科学会雑誌 巻 80, 号 1, p. 17-21, 発行日 1989-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-5287 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00196577 | |||||
出版者 | ||||||
出版者 | 日本泌尿器科学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 継代培養細胞株 (B16-F10メラノーマ, ヒト膀胱癌由来培養細胞株KK-47) および臨床材料 (腎細胞癌5例, 尿路移行上皮癌9例) を用いて鶏卵法による温熱と抗癌剤併用効果の検討を行なった. その結果マウスB16-F10メラノーマではADR単独処理群およびCDDP+温熱, ADR+温熱, CY+温熱併用群において有意に高い腫瘍発育阻止率が認められた (P<0.05, P<0.01). KK-47ではCY単独処理群およびCY+温熱処理群において有意に高い腫瘍発育阻止率が認められた (P<0.05). 臨床材料を用いた検討では14例中11例 (79%) において感受性試験の評価が可能であり, 今後これらの結果を臨床応用し, その相関性につき検討していく予定である. The chorioallantoic membarane of chick embryo was used to examine the responses of tumor cell lines and surgically resected specimens to anticancer agents in combination with or without hyperthermia. B16-F10 melanoma, KK-47 cell line derived from a transitional cell carcinoma of the bladder and surgical specimens from urological malignancies were transplanted onto the chorioallantoic membrane of chick embryo 10 days after fertilization. The effects of intravascularlly injected cyclophosphamide, cisplatin, adriamycin, mitomycin C, vincristine and vinblastine, in combination with or without hyperthermia, on the growth of the grafts were investigated. A 15-minute 42.5°C hyperthermia exhibited most favorable anticancer effects in B16-F10 grafts (P<0.01) of all heating conditions tested. A combined use of hyperthermia and cisplatin, cyclophosphamide or adriamycin demonstrated a significantly high tumor regression rate in B16-F10 grafts (P<0.01). In KK-47 grafts, a single use of cyclophosphamide and a combined use of hyperthermia and cyclophosphamede exhibited a highly significant antitumor regression (P<0.05). Surgical specimens from 14 urological malignancies were subjected to this assay. Growth which was adequate for sensitivity test was obtained in 11 of the 14 malignancies. The results obtained suggest that this assay system may be a useful chemohyperthermia sensitivity test. | |||||
権利 | ||||||
権利情報 | Copyright © 社団法人 日本泌尿器科学会 / 許可を得て登録 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://japanlinkcenter.org/JST.Journalarchive/jpnjurol1989/80.17 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/article/jpnjurol1989/80/1/80_1_17/_article/-char/ja/ |