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MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6
https://doi.org/10.24517/00027503
https://doi.org/10.24517/00027503d0725202-b9d8-48bc-ad87-82765dd7c458
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00027503 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Yoshida, Akiyo
× Yoshida, Akiyo× Kitajima, Shunsuke× Li, Fengkai× Cheng, Chaoyang× Takegami, Yujiro× Kohno, Susumu× Wan, Yuan Song× Hayashi, Naoyuki× Muranaka, Hayato× Nishimoto, Yuuki× Nagatani, Naoko× Nishiuchi, Takumi× Thai, Tran C× Suzuki, Sawako× Nakao, Shinji× Tanaka, Tomoaki× Hirose, Osamu× Barbie, David A.× Takahashi, Chiaki |
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著者別表示 |
北嶋, 俊輔
× 北嶋, 俊輔× 河野, 晋× 林, 直之× 西内, 巧× 中尾, 眞二× 高橋, 智聡 |
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書誌情報 |
Oncotarget 巻 8, 号 8, p. 13872-13885, 発行日 2017-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1949-2553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.14681 | |||||
出版者 | ||||||
出版者 | Impact Journals LLC | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We established an in vitro cell culture system to determine novel activities of the retinoblastoma (Rb) protein during tumor progression. Rb depletion in p53-null mouse-derived soft tissue sarcoma cells induced a spherogenic phenotype. Cells retrieved from Rb-depleted spheres exhibited slower proliferation and less efficient BrdU incorporation, however, much higher spherogenic activity and aggressive behavior. We discovered six miRNAs, including mmu-miR-18a, -25, -29b, -140, -337, and -1839, whose expression levels correlated tightly with the Rb status and spherogenic activity. Among these, mmu-miR-140 appeared to be positively controlled by Rb and to antagonize the effect of Rb depletion on spherogenesis and tumorigenesis. Furthermore, among genes potentially targeted by mmu-miR-140, Il-6 was upregulated by Rb depletion and downregulated by mmu-mir-140 overexpression. Altogether, we demonstrate the possibility that mmu-mir-140 mediates the Rb function to downregulate Il-6 by targeting its 3'-untranslated region. Finally, we detected the same relationship among RB, hsa-miR-140 and IL-6 in a human breast cancer cell line MCF-7. Because IL-6 is a critical modulator of malignant features of cancer cells and the RB pathway is impaired in the majority of cancers, hsa-miR-140 might be a promising therapeutic tool that disrupts linkage between tumor suppressor inactivation and pro-inflammatory cytokine response. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Supplementary Table1 and Supplementary Table2: We offer the table data with an Excel file | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |