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Wnt signaling stimulates transcriptional outcome of the hedgehog pathway by stabilizing GLI1 mRNA
https://doi.org/10.24517/00027535
https://doi.org/10.24517/00027535d45e6c2d-8dbe-44cb-8f6e-217491e1814f
名前 / ファイル | ライセンス | アクション |
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CA-PR-MINAMOTO-T-8572.pdf (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Wnt signaling stimulates transcriptional outcome of the hedgehog pathway by stabilizing GLI1 mRNA | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00027535 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Noubissi, Felicite K.
× Noubissi, Felicite K.× Goswami, Srikanta× Sanek, Nicholas A.× Kawakami, Kazuyuki× Minamoto, Toshinari× Moser, Amy× Grinblat, Yevgenya× Spiegelman, Vladimir S. |
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著者別表示 |
川上, 和之
× 川上, 和之× 源, 利成 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん研究所分子標的がん医療研究開発センター | |||||
書誌情報 |
Cancer Research 巻 69, 号 22, p. 8572-8578, 発行日 2009-11-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0008-5472 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00598557 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1158/0008-5472.CAN-09-1500 | |||||
出版者 | ||||||
出版者 | American Association for Cancer Research | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Wnt and Hedgehog signaling pathways play central roles in embryogenesis, stem cell maintenance, and tumorigenesis. However, the mechanisms by which these two pathways interact are not well understood. Here, we identified a novel mechanism by which Wnt signaling pathway stimulates the transcriptional output of Hedgehog signaling. Wnt/β-catenin signaling induces expression of an RNA-binding protein, CRD-BP, which in turn binds and stabilizes GLI1 mRNA, causing an elevation of GLI1 expression and transcriptional activity. The newly described mode of regulation of GLI1 seems to be important to several functions of Wnt, including survival and proliferation of colorectal cancer cells. ©2009 American Association for Cancer Research. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |