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Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish
http://hdl.handle.net/2297/39042
http://hdl.handle.net/2297/39042beb0224e-08a5-41a8-bcf9-ad027b61d270
名前 / ファイル | ライセンス | アクション |
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SC-PR-SUZUKI-N-6365.pdf (332.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yachiguchi, Koji
× Yachiguchi, Koji× Matsumoto, Noriko× Haga, Yuki× Suzuki, Motoharu× Matsumura, Chisato× Tsurukawa, Masahiro× Okuno, Toshihiro× Nakano, Takeshi× Kawabe, Kimi× Kitamura, Kei-ichiro× Toriba, Akira× Hayakawa, Kazuichi× Chowdhury, Vishwajit S.× Endo, Masato× Chiba, Atsuhiko× Sekiguchi, Toshio× Nakano, Masaki× Tabuchi, Yoshiaki× Kondo, Takashi× Wada, Shigehito× Mishima, Hiroyuki× Hattori, Atsuhiko× Suzuki, Nobuo |
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書誌情報 |
Environmental Science and Pollution Research 巻 21, 号 10, p. 6365-6372, 発行日 2014-05-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1614-7499 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12106751 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s11356-012-1347-5 | |||||
出版者 | ||||||
出版者 | Ecomed Publishers / Springer Verlag | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To analyze the effect of polychlorinated biphenyl (PCB) 118 on fish bone metabolism, we examined osteoclastic and osteoblastic activities, as well as plasma calcium levels, in the scales of PCB (118)-injected goldfish. In addition, effect of PCB (118) on osteoclasts and osteoblasts was investigated in vitro. Immature goldfish, in which the endogenous effects of sex steroids are negligible, were used. PCB (118) was solubilized in dimethyl sulfoxide at a concentration of 10 ppm. At 1 and 2 days after PCB (118) injection (100 ng/g body weight), both osteoclastic and osteoblastic activities, and plasma calcium levels were measured. In an in vitro study, then, both osteoclastic and osteoblastic activities as well as each marker mRNA expression were examined. At 2 days, scale osteoclastic activity in PCB (118)-injected goldfish increased significantly, while osteoblastic activity did not change significantly. Corresponding to osteoclastic activity, plasma calcium levels increased significantly at 2 days after PCB (118) administration. Osteoclastic activation also occurred in the marker enzyme activities and mRNA expressions in vitro. Thus, we conclude that PCB (118) disrupts bone metabolism in goldfish both in vivo and in vitro experiments. © 2012 The Author(s). | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |