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Effects of low-intensity pulsed ultrasound on osteoclasts: Analysis with goldfish scales as a model of bone
http://hdl.handle.net/2297/47074
http://hdl.handle.net/2297/470741a086d55-efe2-4f09-91c6-d13e4b23cda8
名前 / ファイル | ライセンス | アクション |
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OC-PR-SUZUKI-N-71.pdf (342.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Effects of low-intensity pulsed ultrasound on osteoclasts: Analysis with goldfish scales as a model of bone | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hanmoto, Taizo
× Hanmoto, Taizo× Tabuchi, Yoshiaki× Ikegame, Mika× Kondo, Takashi× Kitamura, Kei-ichiro× Endo, Masato× Kobayashi, Isao× Mishima, Hiroyuki× Sekiguchi, Toshio× Urata, Makoto× Seki, Azusa× Yano, Sachiko× Hattori, Atsuhiko× Suzuki, Nobuo |
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書誌情報 |
Biomedical Research (Japan) 巻 38, 号 1, p. 71-77, 発行日 2017-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0388-6107 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00110128 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2220/biomedres.38.71 | |||||
出版者 | ||||||
出版者 | Biomedical Research Foundation = 東京生化学研究会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effects of low-intensity pulsed ultrasound (LIPUS) on osteoclastogenesis were examined using fish scales that had both osteoclasts and osteoblasts. The binding of the receptor activator of NF-κB ligand (RANKL) in osteoblasts to the receptor activator of NF-κB (RANK) in osteoclasts induced osteoclastogenesis. Therefore, we focused on RANK/RANKL signaling. After 6 h of incubation following LIPUS treatment, mRNA expression of RANKL increased significantly. Resulting from the increased RANKL mRNA level, the expression of transcription-regulating factors significantly increased after 6 h of incubation, and then the mRNA expression of functional genes was significantly up-regulated after 12 h of incubation. However, the mRNA expression of osteoprotegerin (OPG), which is known as an osteoclastogenesis inhibitory factor, also significantly increased after 6 h of incubation and tended to further increase after 12 h of incubation. At 24 h of incubation, osteoclastic functional genes’ mRNA expression decreased to the level of the control. Furthermore, we performed an in vivo experiment with goldfish. Two weeks after daily LIPUS exposure, osteoclastic marker enzymes tended to decrease while osteoblastic marker enzymes were activated. The regeneration rate of the LIPUS-treated scales was significantly higher than that of the control scales. Thus, LIPUS moderately activates osteoclasts and induces bone formation. © 2017 Biomedical Research Foundation. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/biomedres | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.tokyobrf.or.jp/ |