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The emerging roles of RUNX transcription factors in epithelial-mesenchymal transition
http://hdl.handle.net/2297/48404
http://hdl.handle.net/2297/48404f1b6ea2b-3078-457e-ac69-f9c855ca305b
名前 / ファイル | ライセンス | アクション |
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FR-PR-VOON-D.C.-C.-471.pdf (256.7 kB)
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Item type | 一般雑誌記事 / Article(1) | |||||
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公開日 | 2017-12-05 | |||||
タイトル | ||||||
タイトル | The emerging roles of RUNX transcription factors in epithelial-mesenchymal transition | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | article | |||||
著者 |
Voon, Dominic Chih-Cheng
× Voon, Dominic Chih-Cheng× Thiery, Jean Paul |
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書誌情報 |
RUNX Proteins in Development and Cancer/Advances in Experimental Medicine and Biology 号 AEMB, volume 962, p. 471-489, 発行日 2017-03-16 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0065-2598 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00512642 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/978-981-10-3233-2_28 | |||||
出版者 | ||||||
出版者 | Springer New York LLC | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epithelial-mesenchymal transition (EMT) is an evolutionary conserved morphogenetic program necessary for the shaping of the body plan during development. It is guided precisely by growth factor signaling and a dedicated network of specialised transcription factors. These are supported by other transcription factor families serving auxiliary functions during EMT, beyond their general roles as effectors of major signaling pathways. EMT transiently induces in epithelial cells mesenchymal properties, such as the loss of cell-cell adhesion and a gain in cell motility. Together, these newly acquired properties enable their migration to distant sites where they eventually give rise to adult epithelia. However, it is now recognized that EMT contributes to the pathogenesis of several human diseases, notably in tissue fibrosis and cancer metastasis. The RUNX family of transcription factors are important players in cell fate determination during development, where their spatio-temporal expression often overlaps with the occurrence of EMT. Furthermore, the dysregulation of RUNX expression and functions are increasingly linked to the aberrant induction of EMT in cancer. The present chapter reviews the current knowledge of this emerging field and the common themes of RUNX involvement during EMT, with the intention of fostering future research. © Springer Nature Singapore Pte Ltd. 2017. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | [Book Chapter] / Embargo Period 12 months | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
シリーズ | ||||||
関連名称 | Part of the Advances in Experimental Medicine and Biology book series |