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視神経再生中に見られる山中因子の活性化機構と神経再生における役割について
https://doi.org/10.24517/00034542
https://doi.org/10.24517/000345420084398e-dfc1-4b3f-ac9b-39fb9a05d1ab
名前 / ファイル | ライセンス | アクション |
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ME-PR-KATO-S-kanen 2013-4p.pdf (454.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 視神経再生中に見られる山中因子の活性化機構と神経再生における役割について | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A role of Yamanaka's factor during fish optic nerve regeneration after nerve injury | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034542 | |||||
ID登録タイプ | JaLC | |||||
著者 |
加藤, 聖
× 加藤, 聖 |
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著者別表示 |
Kato, Satoru
× Kato, Satoru |
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書誌情報 |
平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2012 Fiscal Year Final Research Report 巻 2011-2012, p. 4p., 発行日 2013-05-16 |
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出版者 | ||||||
出版者 | 金沢大学医学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 哺乳類と異なり魚の視神経は損傷を受けても再生する。なぜ再生できるのかを考えたとき、我々は視神経損傷により網膜神経節細胞(RGCs)が幼若化するのではないかと考え、神経幹細胞のマーカーや山中因子について検討したところ、山中因子のsox2, klf4, c-myc が損傷2-3日で、RGCsで活性化し、その後幹細胞マーカー、ネスチンも活性化することを見出した。このシグナルカスケードについて検討したところ、LIF(リューケミア インヒビトリー ファクター)が1~2日と最も早期に活性化することを見つけ、LIF以降のカスケードについて現在検討中である。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Unlike mammals, fish optic nerve can regenerate after nerve injury. We have a hypothesis of this regenerative capacity of fish optic nerve that mature retinal ganglion cells (RGCs) in fish are reprogrammed to neural stem-cell like cells by optic nerve injury. To certain this hypothesis, we investigated expression levels of sox2, klf4, c-myc and nestin in the zebrafish retina after optic nerve injury. The levels of sox2, klf4 and c-myc mRNA increased in the retina 3 days after axotomy. The level of a neural stem cell marker, nestin increased in the retina 4-5 days after axotomy. These molecules were all localized to the RGCs. Furthermore, we found that leukemia inhibitory factor (LIF) was positional as an upstream signal to the klf4 and sox2. In the presence of LIF in culture medium of retinal explant, a significant neurite outgrowth could be seen as compared to the no treatment, control. In contrast, the inhibition of LIF signals leaded to the suppression of neurite outgrowth from retina. Therefore, we conclude that the capability of fish optic nerve regeneration is due to reprograming mechanism of matured RGCs after optic nerve injury. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:23650163, 研究期間(年度):2011-2012 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「視神経再生中に見られる山中因子の活性化機構と神経再生における役割について」研究課題番号23650163 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23650163/23650163seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10019614 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10019614 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650163/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650163/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23650163/23650163seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23650163/23650163seika/ |