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膜型マトリックスメタロプロテアーゼー1のがん悪性化形質に果たす役割の解析
https://doi.org/10.24517/00034600
https://doi.org/10.24517/00034600f6354d0f-e0eb-4461-9d58-d2135404e6ab
名前 / ファイル | ライセンス | アクション |
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CA-PR-SATO-H-kaken 2012-4p.pdf (242.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 膜型マトリックスメタロプロテアーゼー1のがん悪性化形質に果たす役割の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Study on role of membrane-type matrix metalloproteinase-1 in tumor malignancy | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034600 | |||||
ID登録タイプ | JaLC | |||||
著者 |
佐藤, 博
× 佐藤, 博 |
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著者別表示 |
Satoh, Hiroshi
× Satoh, Hiroshi |
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書誌情報 |
平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2011 Fiscal Year Final Research Report 巻 2009-2011, p. 4p., 発行日 2012-05-18 |
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出版者 | ||||||
出版者 | 金沢大学がん進展制御研究所 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | がんの浸潤・転移に重要な役割を果たすMT1-MMPの新規基質の探索を行い、その生理・病理的意義を解明した。その結果、膜タンパクの切断・シェディングに特にユニークな活性を見出した。例えば、MT1-MMPによるセリンプロテアーゼ阻害因子Hepatocyte Growth Factor Activator Inhibitor-1の切断はプロテアーゼ活性化カスケイドを始動させ組織破壊を引き起こす。我々はその状態をプロテアーゼストームと名付けた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We screened new substrates for MT1-MMP, which plays an important role in tumor invasion and metastasis, and analyzed pathophysiologicanl significance of it. These studies demonstrated that cleavage and shedding of membrane proteins by MT1-MMP is quite unique. For example, cleavage of serine protease inhibitor Hepatocyte Growth Factor Activator Inhibitor-1 by MT1-MMP initiates protease activation cascade, which subsequently causes tissue destruction. We named it as protease storm. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「膜型マトリックスメタロプロテアーゼー1のがん悪性化形質に果たす役割の解析」課題番号21390091 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390091/21390091seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=00115239 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390091/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390091/21390091seika/ |