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肝発生分化メカニズムに基づいた肝癌幹細胞特異的治療法の開発
https://doi.org/10.24517/00034639
https://doi.org/10.24517/0003463966ec2ead-d97f-4596-ad95-e62b81bc1803
名前 / ファイル | ライセンス | アクション |
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HO-PR-YAMASHITA-T-kaken 2011-4p.pdf (307.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 肝発生分化メカニズムに基づいた肝癌幹細胞特異的治療法の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Differentiation of liver cancer stem cells | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034639 | |||||
ID登録タイプ | JaLC | |||||
著者 |
山下, 太郎
× 山下, 太郎 |
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著者別表示 |
Yamashita, Taro
× Yamashita, Taro |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008-2010, p. 4p., 発行日 2011-05-18 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 近年肝癌組織においても幹細胞様の性格を有する肝癌幹細胞の存在が明らかになり、癌治療の重要なターゲットと考えられている。本研究では、正常胎児肝において肝芽細胞を肝細胞へと分化誘導するサイトカインとして知られるOncostatin M(OSM)が肝がん幹細胞の分化誘導に応用可能であることを同定した。OSMは肝癌幹細胞の抗癌剤抵抗性を改善することから、癌治療における有力な標的分子であると考えられた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent evidence suggests that tumor cells possess stem cell features (cancer stem cells) to self-renew and give rise to relatively differentiated cells through asymmetric division, thereby forming heterogeneous populations. Cancer stem cells are considered to be resistant to chemotherapy and radiotherapy, which might be associated with the recurrence of the tumor after treatment. Oncostatin M (OSM) is a pleiotropic cytokine known to activate the hepatocytic differentiation program in hepatoblasts in an OSMR-specific manner. We identified that OSMR is expressed in a subset of liver cancer stem cells and OSM induces hepatocytic differentiation of these cells. OSM-mediated hepatocytic differentiation effectively suppressed HCC growth when combined with conventional chemotherapy, suggesting the utility of OSM for the treatment of liver cancer stem cells. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:20599005, 研究期間(年度):2008–2010 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「肝発生分化メカニズムに基づいた肝癌幹細胞特異的治療法の開発」課題番号20599005 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20599005/20599005seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=90377432 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20599005/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20599005/20599005seika/ |