WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "2bbb68a3-c28a-46e1-b5a8-97a2162494d5"}, "_deposit": {"created_by": 3, "id": "39997", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "39997"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00039997", "sets": ["3021"]}, "author_link": ["63422", "366", "63420", "63421"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-09-24", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "38", "bibliographicPageStart": "384010", "bibliographicVolumeNumber": "19", "bibliographic_titles": [{"bibliographic_title": "Nanotechnology"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "福間, 剛士"}], "nameIdentifiers": [{"nameIdentifier": "366", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90452094", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90452094"}, {"nameIdentifier": "90452094", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90452094"}, {"nameIdentifier": "90452094", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090452094"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We have investigated the surface structure of islet amyloid polypeptide (IAPP) fibrils and α-synuclein protofibrils in liquid by means of frequency modulation atomic force microscopy (FM-AFM). Ångström- resolution FM-AFM imaging of isolated macromolecules in liquid is demonstrated for the first time. Individual β-strands aligned perpendicular to the fibril axis with a spacing of 0.5 nm are resolved in FM-AFM images, which confirms cross-β structure of IAPP fibrils in real space. FM-AFM images also reveal the existence of 4 nm periodic domains along the axis of IAPP fibrils. Stripe features with 0.5 nm spacing are also found in images of α-synuclein protofibrils. However, in contrast to the case for IAPP fibrils, the stripes are oriented 30° from the axis, suggesting the possibility of β-strand alignment in protofibrils different from that in mature fibrils or the regular arrangement of thioflavin T molecules present during the fibril preparation aligned at the surface of the protofibrils. © IOP Publishing Ltd.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学フロンティアサイエンス機構", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00039984", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Institute of Physics"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1088/0957-4484/19/38/384010", "subitem_relation_type_select": "DOI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10863359", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0957-4484", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fukuma, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "366", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90452094", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90452094"}, {"nameIdentifier": "90452094", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90452094"}, {"nameIdentifier": "90452094", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090452094"}]}, {"creatorNames": [{"creatorName": "Mostaert, Anika S."}], "nameIdentifiers": [{"nameIdentifier": "63420", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Serpell, Louise C."}], "nameIdentifiers": [{"nameIdentifier": "63421", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jarvis, Suzanne P."}], "nameIdentifiers": [{"nameIdentifier": "63422", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "FS-PR-FUKUMA-T-384010.pdf", "filesize": [{"value": "118.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 118900.0, "url": {"label": "FS-PR-FUKUMA-T-384010.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/39997/files/FS-PR-FUKUMA-T-384010.pdf"}, "version_id": "1188946a-59c8-4f1a-8429-4616439dc98b"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy"}]}, "item_type_id": "4", "owner": "3", "path": ["3021"], "permalink_uri": "https://doi.org/10.24517/00039984", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-06"}, "publish_date": "2017-10-06", "publish_status": "0", "recid": "39997", "relation": {}, "relation_version_is_last": true, "title": ["Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy"], "weko_shared_id": 3}
Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy
https://doi.org/10.24517/00039984
https://doi.org/10.24517/000399840a776120-ecc4-4957-9cef-c6c1774a8ed4
名前 / ファイル | ライセンス | アクション |
---|---|---|
FS-PR-FUKUMA-T-384010.pdf (118.9 kB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-06 | |||||
タイトル | ||||||
タイトル | Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00039984 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Fukuma, Takeshi
× Fukuma, Takeshi× Mostaert, Anika S.× Serpell, Louise C.× Jarvis, Suzanne P. |
|||||
著者別表示 |
福間, 剛士
× 福間, 剛士 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学フロンティアサイエンス機構 | |||||
書誌情報 |
Nanotechnology 巻 19, 号 38, p. 384010, 発行日 2008-09-24 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0957-4484 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10863359 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1088/0957-4484/19/38/384010 | |||||
出版者 | ||||||
出版者 | Institute of Physics | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have investigated the surface structure of islet amyloid polypeptide (IAPP) fibrils and α-synuclein protofibrils in liquid by means of frequency modulation atomic force microscopy (FM-AFM). Ångström- resolution FM-AFM imaging of isolated macromolecules in liquid is demonstrated for the first time. Individual β-strands aligned perpendicular to the fibril axis with a spacing of 0.5 nm are resolved in FM-AFM images, which confirms cross-β structure of IAPP fibrils in real space. FM-AFM images also reveal the existence of 4 nm periodic domains along the axis of IAPP fibrils. Stripe features with 0.5 nm spacing are also found in images of α-synuclein protofibrils. However, in contrast to the case for IAPP fibrils, the stripes are oriented 30° from the axis, suggesting the possibility of β-strand alignment in protofibrils different from that in mature fibrils or the regular arrangement of thioflavin T molecules present during the fibril preparation aligned at the surface of the protofibrils. © IOP Publishing Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |