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Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum
https://doi.org/10.24517/00042066
https://doi.org/10.24517/00042066840b1eb4-577d-43e1-bf84-6a6756a0ac18
名前 / ファイル | ライセンス | アクション |
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CH-PR-HIGASHIDA-H-17.pdf (453.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-18 | |||||
タイトル | ||||||
タイトル | Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00042066 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Higashida, Haruhiro
× Higashida, Haruhiro× Kamimura, Shin-ya× Inoue, Takeshi× Hori, Osamu× Islam, Mohammad Saharul× Lopatina, Olga× Tsuji, Chiharu |
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著者別表示 |
東田, 陽博
× 東田, 陽博× 堀, 修× 辻, 知陽 |
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書誌情報 |
Journal of Neural Transmission 巻 125, 号 1, p. 17-24, 発行日 2018-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0300-9564 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10850492 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00702-016-1666-7 | |||||
出版者 | ||||||
出版者 | Springer-Verlag | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The role of cyclic ADP-ribose (cADPR) as a second messenger and modulator of the mTOR pathway downstream of dopamine (DA) receptors and/or CD38 was re-examined in the mouse. ADP-ribosyl activity was low in the membranes of neonates, but DA stimulated it via both D1- and D2-like receptors. ADP-ribosyl cyclase activity increased significantly during development in association with increased expression of CD38. The cADPR binding proteins, FKBP12 and FKBP12.6, were expressed in the adult mouse striatum. The ratio of phosphorylated to non-phosphorylated S6 kinase (S6K) in whole mouse striatum homogenates decreased after incubation of adult mouse striatum with extracellular cADPR for 5 min. This effect of cADPR was much weaker in MPTP-treated Parkinson’s disease model mice. The inhibitory effects of cADPR and rapamycin were identical. These data suggest that cADPR is an endogenous inhibitor of the mTOR signaling pathway downstream of DA receptors in the mouse striatum and that cADPR plays a certain role in the brain in psychiatric and neurodegenerative diseases. © 2016 Springer-Verlag Wien | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 12 months | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |