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宿主との折り合いをつける細菌遺伝子の同定と機能解明
https://doi.org/10.24517/00049472
https://doi.org/10.24517/00049472385d9903-355f-46dd-900a-a2d89418cca0
名前 / ファイル | ライセンス | アクション |
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PH-PR-NAKANISHI-Y-2016B-6p.pdf (207.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-12-21 | |||||
タイトル | ||||||
タイトル | 宿主との折り合いをつける細菌遺伝子の同定と機能解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification and characterization of bactrial genes for coexistence with hosts | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00049472 | |||||
ID登録タイプ | JaLC | |||||
著者 |
中西, 義信
× 中西, 義信 |
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著者別表示 |
Nakanishi, Yoshinobu
× Nakanishi, Yoshinobu |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
書誌情報 |
平成27(2015)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2015 Fiscal Year Final Research Report 巻 2014-04-01 – 2016-03-31, p. 6p., 発行日 2016-04-29 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 細菌感染において、生存が途絶えない程度に細菌増殖が抑えられ、菌量が過剰にならない程度に免疫反応が起これば、“細菌は排除されず宿主が病気にならない状態”がつくり出される可能性が高い。本研究では、ショウジョウバエをモデル宿主として、このような宿主と細菌との折り合いをもたらす細菌遺伝子が探索された。その結果、大腸菌の二成分制御系の一つであるEnvZ-OmpRをコードする遺伝子が見つかった。この“折り合い遺伝子”envZ-ompRは、外膜タンパク質OmpCの発現を誘導して細菌の宿主殺傷性を低下させてショウジョウバエと大腸菌の共存を導くと考えられた。この発見は新規の細菌感染症対策につながると期待される。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bacterial infection often causes serious diseases. This could be avoided when the virulence of bacteria is kept sufficiently low. We hypothesize that bacteria possess a gene(s) that creates the coexistence of hosts and invading bacteria. This study was undertaken to identify such a bacterial gene using Escherichia coli and Drosophila melanogaster as a model bacterium and host, respectively. We identified envZ-ompR, a pair of genes coding for the two-component regulatory system EnvZ-OmpR, that mitigates the virulence of E. coli in Drosophila. The enhanced expression of envZ-ompR and the phosphorylation of EnvZ were observed under infectious state. Forced expression of ompC, one of the target genes of EnvZ-OmpR, rescued the virulence phenotype of an envZ-ompR mutant. OmpC as an outer membrane protein has been known to protect bacteria from a change of osmotic pressure. The mechanisms of the induction of envZ-ompR and a mode of actions of OmpC await further investigation. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:25291021, 研究期間(年度):2013-04-01 – 2016-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「宿主との折り合いをつける細菌遺伝子の同定と機能解明」課題番号25291021 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25291021/25291021seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=40172358 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=40172358 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25291021/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25291021/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25291021/25291021seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25291021/25291021seika/ |