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A 4-year trial of simvastatin in the treatment of patients with heterozygous familial hypercholesterolemia
https://doi.org/10.24517/00049722
https://doi.org/10.24517/0004972267ef5a34-9cc4-46d8-b087-bcaffe16dd8d
名前 / ファイル | ライセンス | アクション |
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ME-PR-INAZU-A-62 (503.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-11 | |||||
タイトル | ||||||
タイトル | A 4-year trial of simvastatin in the treatment of patients with heterozygous familial hypercholesterolemia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00049722 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Kitatani, Masako
× Kitatani, Masako× Koizumi, Junji× Inazu, Akihiro× Kajinami, Kouji× Mabuchi, Hiroshi |
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著者別表示 |
小泉, 順二
× 小泉, 順二× 稲津, 明広× 梶波, 康二× 馬渕, 宏 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
Topics in Catalysis 巻 57, 号 1, p. 62-71, 発行日 1996-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0011-393X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00622254 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/S0011-393X(96)80031-2 | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A study was conducted to determine the clinical efficacy and tolerability of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase in seven patients with heterozygous familial hypercholesterolemia (FH) (defined as primary hypercholesterolemia with tendon xanthoma or primary hypercholesterolemia without tendon xanthomas and at least one first-degree relative with familial hypercholesterolemia). These patients were administrated 10 mg/d of simvastatin for up to 4 years. Simvastatin significantly reduced levels of both total cholesterol and low-density lipoprotein cholesterol during treatment; respective reduction rates were 28% and 34% after 1 month and 32% and 40% after 4 years. Serum high-density lipoprotein cholesterol levels slightly and insignificantly increased. Serum triglyseride levels fell significantly by 24% at month 6. After this study, all xanthomas had reduced in size. No adverse events related to simvastatin were observed. We conclude that long-term simvastatin therapy is clinically useful and well tolerated in patients with FH. Copyright © 1985 Published by Elsevier Inc. | |||||
権利 | ||||||
権利情報 | Copyright © 1985 Published by Elsevier Inc. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/locate/issn/0011393X | |||||
関連名称 | http://www.elsevier.com/locate/issn/0011393X |