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ミトコンドリアと神経細胞死
https://doi.org/10.24517/00050071
https://doi.org/10.24517/00050071e7d6a38a-e19e-4c58-817d-f70b98d8f2ca
名前 / ファイル | ライセンス | アクション |
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PH-PR-YONEDA-Y-kaken 2012-4p.pdf (204.8 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-02-09 | |||||
タイトル | ||||||
タイトル | ミトコンドリアと神経細胞死 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Neuronal cell death mediated by mitochondria | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050071 | |||||
ID登録タイプ | JaLC | |||||
著者 |
米田, 幸雄
× 米田, 幸雄 |
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著者別表示 |
Yoneda, Yukio
× Yoneda, Yukio |
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書誌情報 |
平成23(2011)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2011 Fiscal Year Final Research Report 巻 2009-2011, p. 4p., 発行日 2012-05-01 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域薬学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | GluやNMDAに対する脆弱性相違に、ミトコンドリア膜電位、mPTP形成能、ミトコンドリア内Ca^<2+>濃度、およびUCP2発現量等の相違が少なくとも一部は関与する可能性が判明した。人工的NMDARチャネルにさらにUCP2発現ベクターを導入すると、NMDA曝露に伴ってミトコンドリア内遊離Ca^<2+>濃度の著明な上昇とともに、著明な細胞死が出現した。海馬神経細胞におけるNMDA毒性脆弱性の出現には、ミトコンドリア内膜に発現するUCP2発現量が関与すると推察される。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Glutamate neurotoxicity was found to at least in part involve mitochondrial membrane potential disruption, mPTP orchestration, mitochondrial free Ca^<2+> levels and UCP2 expression in rat hippocampal and cortical neurons. In HEK293 cells with acquired NMDAR channels and overexpressed UCP2, a more marked increase was seen in mitochondrial free Ca^<2+> levels, in addition to more severe cell death, after the exposure to NMDA than in cells without UCP2 overexpression. Accordingly, UCP2 could play a role as a determinant of the neurotoxicity mediated by NMDAR through a mechanism related to the modulation of mitochondrial free Ca^<2+> levels in neurons. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:21659018, 研究期間(年度):2009-2011 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「ミトコンドリアと神経細胞死」課題番号21659018 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659018/21659018seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50094454 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50094454 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659018/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659018/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659018/21659018seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659018/21659018seika/ |