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最小単位オミクス総合解析による乳がん組織多様性の解明
https://doi.org/10.24517/00050105
https://doi.org/10.24517/000501050e388854-5bcb-404f-a119-2cfe05d1f04b
名前 / ファイル | ライセンス | アクション |
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CA-PR-GOTO-N-kaken 2018-6p.pdf (1.4 MB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-04-06 | |||||
タイトル | ||||||
タイトル | 最小単位オミクス総合解析による乳がん組織多様性の解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation of breast cancer tissue diversity by integration analysis of minimum unit omics | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050105 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Gotoh, Noriko
× Gotoh, Noriko |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん進展制御研究所 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2015-04-01 – 2018-03-31, p. 6p., 発行日 2018-06-01 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | がん組織は非常に不均一であるため、細胞群を1細胞に分離して解析することが重要である。本研究では乳がん臨床検体からがん幹細胞を高密度に濃縮できる申請者独自の手法と、転写産物を正確に網羅的に解析する最新の技術を用いて、がん幹細胞から分化がん細胞へ至るヒエラルキーの解明を目指した。その結果、分化がん細胞集団に比較し、がん幹細胞集団は、遺伝子発現パターンのばたつきが大きく、がん幹細胞から前駆細胞へ至って遺伝子発現が大きくかわるヒエラルキーの存在が示唆された。その中から、鍵分子候補を同定し、qPCRで発現確認し、がん幹細胞の維持とヒエラルキーの形成に重要な役割を果たすことが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cancer tissues are composed of very heterogenous cell populations, including cancer stem cells, progenitor cancer cells and differentiated cancer cells. It is thus important to clarify the characteristics of each cell type at single cell levels. The aim of this study to clarify the molecular mechanisms how cancer stem cells are maintained in the caner stem cell niche by analyzing transcriptome at single cell levels. We have clarified the semaphorin-neuropilin (NP) signal plays critical roles for breast cancer stem cells. We sorted NP-positive and control NP-negative cell population derived from breast cancer patient samples and analyzed transcriptome at single cell levels by using the cutting-edge technologies. We found that NP-positive cell population show strong variance in mRNA expression patterns than NP-negative cell population. These findings suggest that NP-positive cells are composed of more heterogenous cell populations with clear hierarchy than NP-negative cells. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15H04294, 研究期間(年度):2015-04-01 – 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「最小単位オミクス総合解析による乳がん組織多様性の解明」課題番号15H04294 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04294/15H04294seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10251448 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10251448 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04294/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04294/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04294/15H04294seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04294/15H04294seika/ |