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GSK3β経路を標的とする大腸がんの病態解明と治療法開発の基盤形成
https://doi.org/10.24517/00050209
https://doi.org/10.24517/00050209d0ecd28f-b4a3-4927-a93c-9056f2fd866b
名前 / ファイル | ライセンス | アクション |
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CA-PR-MINAMOTO-T-kaken 2018-6p.pdf (835.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-04-06 | |||||
タイトル | ||||||
タイトル | GSK3β経路を標的とする大腸がんの病態解明と治療法開発の基盤形成 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Investigation of biological basis of GSK3beta-targeted therapy and its translation to colorectal cancer treatment | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050209 | |||||
ID登録タイプ | JaLC | |||||
著者 |
源, 俊成
× 源, 俊成 |
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著者別表示 |
Minamoto, Toshinari
× Minamoto, Toshinari |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん進展制御研究所 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2015-04-01 – 2018-03-31, p. 6p., 発行日 2018-09-11 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | グリコーゲン合成酵素キナーゼ(GSK)3βと大腸がん病態の関連をがんの代謝特性やmicro(mi)-RNAなどに着目して解析した。GSK3βは70%の大腸がん症例の腫瘍で発現亢進し、let-7 miRNAの発現と逆相関したが、K-rasやSrcの活性とは相関しなかった。大腸がん細胞と腫瘍組織の代謝における機能解析から、GSK3βはがん促進的な代謝を誘導することを見いだした。GSK3β標的療法のがん治療への応用のため、阻害剤シード化合物の効果の予備検討を行った。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We explored the biological role of glycogen synthase kinase (GSK)3β in colorectal cancer (CRC) progression by focusing on the distinct metabolic profile and micro(mi)-RNA. Expression of GSK3β was increased in 70% of clinical CRC tumors, which was associated inversely with expression of tumor suppressive let-7 miRNA but not with activation of K-ras or Src oncoprotein. Metabolic analysis of GSK3β in CRC cells and tumors found that GSK3β was responsible for tumor-promoting aberrant metabolism. For translation of GSK3β-targeted therapy to cancer treatment, we also conducted preliminary studies on cancer therapeutic effects of GSK3β-inhibiting seed compounds. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15H04928, 研究期間(年度):2015-04-01 – 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「GSK3β経路を標的とする大腸がんの病態解明と治療法開発の基盤形成」課題番号15H04928 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04928/15H04928seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50239323 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50239323 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04928/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04928/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04928/15H04928seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04928/15H04928seika/ |