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固形癌分子標的治療の早期客観的治療効果判定法の確立
https://doi.org/10.24517/00050386
https://doi.org/10.24517/00050386bba810d9-b4df-46b5-97a8-5a756e89033c
名前 / ファイル | ライセンス | アクション |
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ME-PR-KOBAYASHI-S-kaken 2013-5p.pdf (381.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-03-19 | |||||
タイトル | ||||||
タイトル | 固形癌分子標的治療の早期客観的治療効果判定法の確立 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Early prediction of therapeutic effect of molecular targeting therapy for solid malignant tumor with imaging biomarkers | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050386 | |||||
ID登録タイプ | JaLC | |||||
著者 |
小林, 聡
× 小林, 聡 |
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著者別表示 |
Kobayashi, Satoshi
× Kobayashi, Satoshi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2012 Fiscal Year Final Research Report 巻 2010-2012, p. 5p., 発行日 2013-04-18 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域保健学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 肝細胞癌の分子標的治療開始後の腫瘍血管の拡張所見が治療有効例の予測に応用可能と考えられた。Perfusion CTによる治療後早期の血流パラメータ値の変化と長期経過後の腫瘍の画像上変化との間には有意な相関は得られなかった。一方、Dual-Energy CTによる腫瘍内ヨード量定量値は腫瘍の血流と関連があることが示され、早期治療効果判定のバイオマーカーとして使用できる可能性が示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dilatation of intratumoral vessels on multiphasic contrast enhanced CT was estimated to be one of the key findings for prediction of early therapeutic effect evaluation of molecular-targeting therapy for hepatocellular carcinoma (HCC). There are no significant correlation between hemodynamic parameters of CT perfusion just after starting of molecular-targeting therapy for HCC and long term therapeutic effect of it. In contrast, intratumoral iodine measurement obtained by dual-energy CT technique might be used as surrogate marker for early prediction of therapeutic effect of molecular targeting therapy for HCC. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:22591319, 研究期間(年度):2010-2012 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「固形癌分子標的治療の早期客観的治療効果判定法の確立」課題番号22591319 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591319/22591319seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30313638 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30313638 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591319/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591319/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591319/22591319seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591319/22591319seika/ |