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The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells
https://doi.org/10.24517/00050487
https://doi.org/10.24517/000504879fe1fd37-16ff-44b1-8b87-ee0fe84282fe
名前 / ファイル | ライセンス | アクション |
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ME-PR-KANEKO-S-2163.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-13 | |||||
タイトル | ||||||
タイトル | The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050487 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Nasti, Alessandro
× Nasti, Alessandro× Sakai, Yoshio× Seki, Akihiro× Buffa, Geraldine Belen× Komura, Takuya× Mochida, Hatsune× Yamato, Masatoshi× Yoshida, Keiko× Ho, Tuyen T. B.× Takamura, Masayuki× Usui, Soichiro× Wada, Takashi× Honda, Masao× Kaneko, Shuichi |
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著者別表示 |
酒井, 佳夫
× 酒井, 佳夫× 餅田, 初音× 吉田, 佳子× 高村, 雅之× 薄井, 荘一郎× 和田, 隆志× 本多, 政夫× 金子, 周一 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
European Journal of Immunology 巻 47, 号 12, p. 2163-2174, 発行日 2017-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0014-2980 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00639610 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/eji.201646835 | |||||
出版者 | ||||||
出版者 | Wiley | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Stromal cells in adipose tissue are useful for repair/regenerative therapy as they harbor a substantial number of mesenchymal stem cells; therefore, freshly isolated autologous uncultured adipose tissue derived stromal cells (u-ADSCs) are useful for regenerative therapy, and obviate the need for mesenchymal stem cells. We evaluated the therapeutic effect of murine u-ADSCs and sorted subsets of u-ADSCs in a concanavalin A (ConA) induced murine model of hepatitis, as well as their characteristics. We found that 10–20% of u-ADSCs expressed the CD45 leukocyte-related antigen. CD68, which is a marker of macrophages (MΦs), was expressed by 50% of CD45+ u-ADSCs. About 90% of CD68+CD45+ cells expressed CD206 antigen, which is a marker of inhibitory M2-type MΦs. Genes related to M2-type MUs were especially more highly expressed by CD45+CD206+ u-ADSCs than by CD45− u-ADSCs. CD45+ u-ADSCs inhibited the expression of cytokines/chemokines and suppressed the proliferation of splenocytes stimulated with ConA. We observed that not only whole u-ADSCs, but also the CD45+ subset of u-ADSCs ameliorated the ConA-induced hepatitis in mice. In conclusion, we show that freshly isolated murine u-ADSCs were effective against acute hepatitis, and CD45+ u-ADSCs acting phenotypically and functionally like M2-type MΦs, contributed to the repair of liver tissue undergoing inflammation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 12 months | |||||
権利 | ||||||
権利情報 | Copyright © Wiley | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |