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皮膚免疫疾患におけるB細胞抑制性受容体 CD22/72 の制御機構
https://doi.org/10.24517/00050812
https://doi.org/10.24517/00050812e3ceb503-03c4-45e6-ba9b-71609db3b65b
名前 / ファイル | ライセンス | アクション |
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ME-PR-HAMAGUCHI-Y-kaken 2015-4p.pdf (334.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-05-21 | |||||
タイトル | ||||||
タイトル | 皮膚免疫疾患におけるB細胞抑制性受容体 CD22/72 の制御機構 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A role of CD22 and CD72 in the immune responses | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050812 | |||||
ID登録タイプ | JaLC | |||||
著者 |
濱口, 儒人
× 濱口, 儒人 |
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著者別表示 |
Hamaguchi, Yasuhito
× Hamaguchi, Yasuhito |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2014 Fiscal Year Final Research Report 巻 2012-04-01 - 2015-03-31, p. 4p., 発行日 2015-05-27 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究では、CD22とCD72を同時に欠損させたマウス(CD22-/-/CD72-/-マウス)を作成し、CD22とCD72の役割について検討した。CD22-/-/CD72-/-マウスでは野生型マウスに比べ末梢血液中における成熟B細胞の数が有意に減少していた。B細胞のturnover 、血清免疫グロブリン濃度、T細胞依存あるいは非依存抗原に対する免疫応答は、それぞれの単独欠損マウスでみられる異常を越えるものではなかった。また、CD22-/-/CD72-/-マウスでは野生型マウスに比べ自己免疫疾患を発症しやすいことはなかった。以上より、CD22とCD72は独立してB細胞を制御していると考えられた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we addressed whether CD22 and CD72 have redundant functions using CD22 and CD72 double-deficient (CD22-/-/CD72-/-) mice. CD22-/-/CD72-/- mice showed significantly decreased number of peripheral B cells compared to wild type mice. Turnover of B cells in CD22-/-/CD72-/- mice was significantly augmented than in wild type mice, but significantly reduced compared to CD22-/- mice. CD22-/- mice showed significantly increased serum IgM levels compared to wild type mice, but CD22-/-/CD72-/- mice did not. IgM responses against DNP-Ficoll were significantly decreased in CD22-/-/CD72-/- mice compared to wild type mice. In pristane-induced murine lupus model, both the incidence of ANAs and urine protein levels were similar between wild type and CD22-/-/CD72-/- mice. These results showed that abnormalities observed in CD22-/-/CD72-/- mice did not exceed the degree of those seen in each-deficient mice. Therefore, we concluded that CD22 and CD72 independently regulated B cell function. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:24591645 , 研究期間(年度):2012-04-01 - 2015-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「皮膚免疫疾患におけるB細胞抑制性受容体 CD22/72 の制御機構」課題番号24591645 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591645/24591645seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=60420329 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=60420329 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591645/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591645/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591645/24591645seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591645/24591645seika/ |