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血中循環がん細胞解析を利用した小細胞肺癌の新規治療標的・バイオマーカーの同定
https://doi.org/10.24517/00050941
https://doi.org/10.24517/00050941b923c617-742d-48fe-98df-91e52b06644e
名前 / ファイル | ライセンス | アクション |
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ME-PR-KIMURA-H-kaken 2017-4p.pdf (259.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-04 | |||||
タイトル | ||||||
タイトル | 血中循環がん細胞解析を利用した小細胞肺癌の新規治療標的・バイオマーカーの同定 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of Novel Treatment Targets and Biomarkers for Small-Cell Lung Cancer by Circulating Tumor Cell Analysis | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050941 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Kimura, Hideharu
× Kimura, Hideharu |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2014-04-01 - 2017-03-31, p. 4p., 発行日 2017-05-29 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 【CTCを用いた遺伝子発現解析】小細胞肺癌12例の末梢血単核球分画からRNAを抽出し、RT-PCR法にてCTC由来遺伝子発現の解析を行った。神経内分泌関連および上皮間葉移行関連、血管新生関連の遺伝子発現を検討し、上皮間葉移行関連遺伝子発現を検出することができた。本方法でCTC関連遺伝子発現を検出できることが示唆された。 【血中DNAを用いた遺伝子変異解析】進行期肺癌剖検例4例を対象に、腫瘍組織由来のDNAと血中DNAを用いて、次世代シークエンサーにて遺伝子変異を解析した。血中DNA中の遺伝子変異は、複数病変に共通して存在し腫瘍組織内のallele frequencyが有意に高かった。 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [Gene expression analysis using circulating tumor cells (CTCs)] We extracted RNA from the peripheral blood mononuclear cell fraction of 12 small-cell lung cancer patients and analyzed it for CTC-derived gene expression by the reverse transcriptase-polymerase chain reaction (RT-PCR). We investigated neuroendocrine-related, epithelial-mesenchymal-transition-related, and angiogenesis-related gene expression and were able to identify epithelial-mesenchymal transition-related gene expression. The results suggested that it is possible to identify CTC-related gene expression by this method. [Gene mutation analysis using blood DNA] We analyzed tumor tissue derived DNA and blood DNA from 4 autopsy cases of advanced lung cancer by using a next generation sequencer. The same gene mutations as in the blood DNA were present in multiple lesions, and allele frequency in the tumor tissue was significantly higher. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:26430142, 研究期間(年度):2014-04-01 - 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「血中循環がん細胞解析を利用した小細胞肺癌の新規治療標的・バイオマーカーの同定」研究成果報告書 課題番号26430142 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430142/26430142seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=40444202 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=40444202 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430142/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430142/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430142/26430142seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430142/26430142seika/ |