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家族性高コレステロール血症の原因遺伝子別系統的病態解析
https://doi.org/10.24517/00050952
https://doi.org/10.24517/00050952cd3589e9-f3ea-4fb0-8cfc-d8e408738d21
名前 / ファイル | ライセンス | アクション |
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ME-PR-KAWASHIRI-M-kaken 2012-6p.pdf (523.2 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-04 | |||||
タイトル | ||||||
タイトル | 家族性高コレステロール血症の原因遺伝子別系統的病態解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Systematic Analysis of Pathophysiology of Familial Hypercholesterolemia Due to Different Causal Gene Mutations | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050952 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Kawashiri, Masaaki
× Kawashiri, Masaaki |
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書誌情報 |
平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2011 Fiscal Year Final Research Report 巻 2009-2011, p. 6p., 発行日 2012-05-16 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域医学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 常染色体劣性高コレステロール血症のLDL異化率は正常者に比し75%低下し、VLDLの直接異化率は著明に亢進していた。スタチンによりLDL異化率は正常化し、VLDL直接異化率は上昇した。PCSK9遺伝子異常ホモ接合体のLDL異化率は正常者に比し52%低下し、VLDL合成率、VLDL直接異化率はいずれも亢進していた。スタチンによりLDL異化率は正常化したが、VLDL合成率、直接異化率は不変であった。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The fractional catabolic rate(FCR) of low-density lipoprotein(LDL) apolipoprotein B(apoB) in a patient with autosomal recessive hypercholesterolemia(ARH) was 75% smaller, whereas direct removal of very-LDL apoB was dramatically greater compared with those of normal control subjects. Statin therapy normalized FCR of LDL apoB and increased direct removal of very-LDL in ARH patient. On the other hand, the FCR of patients with homozygous proprotein convertase subtilisin/kexin 9(PCSK9) gene mutation was 52% smaller than that of normal control subjects and normalized by statin therapy. Whereas, both production rate and direct removal of very-LDL was increased compared with those of normal control subjects, which were not changed by statin therapy. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:21591160, 研究期間(年度):2009-2011 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「家族性高コレステロール血症の原因遺伝子別系統的病態解析」課題番号21591160 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591160/21591160seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=90345637 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=90345637 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591160/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591160/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591160/21591160seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591160/21591160seika/ |