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蛍光イメージングを用いた骨軟部腫瘍の進展機序解明と治療戦略
https://doi.org/10.24517/00051055
https://doi.org/10.24517/0005105535461092-32c4-4a42-ae9f-66c3b26334d6
名前 / ファイル | ライセンス | アクション |
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ME-PR-TSUCHIYA-H-kaken 2014-6p.pdf (234.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-14 | |||||
タイトル | ||||||
タイトル | 蛍光イメージングを用いた骨軟部腫瘍の進展機序解明と治療戦略 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Treatment strategy and analysis of progression mechanism of musculoskeletal tumors using fluorescent imaging | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051055 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Tsuchiya, Hiroyuki
× Tsuchiya, Hiroyuki |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成25(2013)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2013 Fiscal Year Final Research Report 巻 2011-04-01 - 2014-03-31, p. 6p., 発行日 2014-06-12 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域医学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 蛍光標識骨肉腫細胞をin vivoでの継代で転移能の異なる細胞を作成し転移能が上昇するにつれてPAI-1・u-PAの濃度が上昇していた。カフェインの抗腫瘍効果はPTEN/Akt経路に加え、NF-κB、ERKを抑制することを明らかにした。Fluorescent Ubiquitination-based Cell Cycle Indicatorを用いて、カフェインが細胞周期の停止を阻害し抗癌剤を増強させることが分かった。テオブロミンの作用について検討し、抗腫瘍作用があることが分かった。骨軟部悪性腫瘍の蛍光イメージング目的に、ICGを用いて骨軟部腫瘍患者で施行し手術のナビゲーションとなり得た。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Fluorescent labeled osteosarcoma cell line was transplanted in nude mice and harvested in lung metastasis to obtain higher metastatic cell line. The more metastatic potential, the more PAI -1 and u-PA levels increased. We previously reported that caffeine-assisted chemotherapy. We found caffeine affects tumor cells through various pathways, such as PTEN, AKT, NF-kB, and ERK activities. Modulation of cisplatinum efficacy induced by caffeine was visualized at the subcellular level by fluorescent ubiquitination-based cell cycle indicator in the nucleus. Caffeine overcame the cell-cycle arrest induced by cisplatinum, thereby increasing its efficacy. Theobromine, a caffeine derivative, was investigated as a new anti-cancer effect. It elevates intracellular cAMP levels and inhibits cell proliferation. Surgical navigation for bone and soft tissue tumor in mouse and human was also performed using ICG and near-infrared fluorescent imaging. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:23390360, 研究期間(年度):2011-04-01 - 2014-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「蛍光イメージングを用いた骨軟部腫瘍の進展機序解明と治療戦略」課題番号23390360 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390360/23390360seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=40227434 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=40227434 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390360/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390360/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390360/23390360seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390360/23390360seika/ |