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骨髄不全におけるCXCR4陽性造血幹細胞を標的とした新規治療法の開発
https://doi.org/10.24517/00051101
https://doi.org/10.24517/0005110172946f6c-4b79-4501-8f4e-7590357a7a47
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKAO-S-kaken 2017-4p.pdf (348.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-18 | |||||
タイトル | ||||||
タイトル | 骨髄不全におけるCXCR4陽性造血幹細胞を標的とした新規治療法の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Development of a new therapy targeting CXCR4+ hematopoietic stem cells in patients with bone marrow failure | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051101 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Nakao, Shinji
× Nakao, Shinji |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2015-04-01 - 2017-03-31, p. 4p., 発行日 2017-05-31 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 余剰造血幹前駆細胞(HSPC)のマーカーであるCXCR4陽性のHSCPを活性化できれば、再生不良性貧血(再不貧)患者の造血機能を改善させられる可能性がある。免疫不全マウスの骨髄内にヒトCD34(+)細胞を移植したところ、3.3-20.4%のヒトCD45陽性細胞の再生を確認した。6pLOH陽性の再不貧患者単球由来iPS細胞からHSPCを誘導し、同じマウスに移植したところ、患者体内で優勢であった6pLOH(+)HSPCのCXCR4(+)細胞割合(平均10.2%)は野生型(50.7%)に比べて有意に低値であった。野生型CXCR4(+)HSPCをin vivoで活性化させる方法を現在検討中である。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A chemokine receptor CXCR4 is preferentially expressed by redundant hematopoietic stem/progenitor cells (HSPCs) that do not contribute to hematopoiesis. Stimulation of residual CXCR4(+) HSPCs may restore hematopoietic function of patients with acquired aplastic anemia (AA). First, we optimized method of engrafting an immune-deficient mouse (BRGS mouse) with cord-blood CD34(+) cells using intra-bone marrow injection, and confirmed the presence of human CD45(+) cells that accounted for 3.3-20.4% of the various tissue-derived cells. Next, we induced HSPCs from iPS cells that were generated from monocytes of AA patients possessing 6pLOH(+) leukocytes, which were predominant in the patients’ blood, as a result of uniparental disomy, and injected the HSPCs to the same mice. Regenerating human 6pLOH(+)CD34(+) cells in the mice expressed CXCR4 to a significantly lesser degree (mean 10.2%) than did 6pLOH(-)CD34(+) cells. We are currently exploring a method to activate CXCR4(+) HSPCs in vivo. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15K15360, 研究期間(年度):2015-04-01 - 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「骨髄不全におけるCXCR4陽性造血幹細胞を標的とした新規治療法の開発」研究成果報告書 課題番号15K15360 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15360/15K15360seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=70217660 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=70217660 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15360/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15360/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15360/15K15360seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15360/15K15360seika/ |