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肝細胞癌のMesenchymal Transition機序の解明
https://doi.org/10.24517/00051271
https://doi.org/10.24517/000512713ef638c3-493c-440d-baef-a2203c065dcc
名前 / ファイル | ライセンス | アクション |
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ME-PR-TAKAMURA-H-kaken 2011-4p.pdf (572.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-28 | |||||
タイトル | ||||||
タイトル | 肝細胞癌のMesenchymal Transition機序の解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation of mechanism of mesenchymal transition in HCC | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051271 | |||||
ID登録タイプ | JaLC | |||||
著者 |
高村, 博之
× 高村, 博之 |
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著者別表示 |
Takamura, Hiroyuki
× Takamura, Hiroyuki |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院肝胆膵・移植外科 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008-2010, p. 4p., 発行日 2011-05-16 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ラジオ波焼灼療法(RFA)や肝動脈塞栓療法(TACE)による肝細胞癌(HCC)治療後の肝内局所再発でしばしば見られる治療抵抗性への形質転換(高度な浸潤・転移・増殖能の獲得)であるEpithelial Mesenchymal Transition (EMT)を,臨床検体を用いて明らかにした.さらにin vivo実験系を用いてHCCのEMT化にHIF-1αがきわめて重要な働きをしていることを明らかにし,その阻害剤を用いることでEMT化が抑制されることを証明した. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | I clarified epithelial mesenchymal transition (EMT) which was transformation to treatment resistance to be often seen in local recurrence in the post-treatment (RFA and TACE) liver of the hepatocellular carcinoma (HCC). Furthermore I elucidated the molecular mechanism about EMT of HCC and clarified molecular target to prevent EMT with in vivo experimental model. It was probed that HIF-1 α has had extremely important role in EMT of the HCC and the EMT was restrained by using a repressor of HIF-1α such as valproic acid (VPA). | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「肝細胞癌のMesenchymal Transition機序の解明」課題番号20591603 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591603/20591603seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=40377396 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=40377396 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591603/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591603/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591603/20591603seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591603/20591603seika/ |