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口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討
https://doi.org/10.24517/00051608
https://doi.org/10.24517/000516083ae4c48c-13b9-4800-a0ad-eea156eb271f
名前 / ファイル | ライセンス | アクション |
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HO-PR-KATO-K-kanen 2011-5p.pdf (214.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-07-09 | |||||
タイトル | ||||||
タイトル | 口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Examination of the suppressant effect of progression, invasion and metastasis in oral squamous cell carcinoma by AMPK activated reagent | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051608 | |||||
ID登録タイプ | JaLC | |||||
著者 |
加藤, 公禄
× 加藤, 公禄 |
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著者別表示 |
Kato, Koroku
× Kato, Koroku |
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書誌情報 |
平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008-2010, p. 5p., 発行日 2011-05-17 |
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出版者 | ||||||
出版者 | 金沢大学附属病院歯科口腔外科 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | MTS assayならびにWestern blotにてAMPK活性化薬剤であるAICARの口腔扁平上皮癌細胞の増殖抑制効果とアポトーシス関連蛋白の変動について検討を行った。その結果、AICARの濃度依存的、時間依存的な細胞増殖抑制効果が確認された。また、それに伴いAMPKα、Phospho-AMPKα、bax、p53の経時的な発現増加ならびにbcl-2、PCNAの経時的な発現減弱を認めた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The suppressant effect of progression and the time-dependent change of the apoptotic related protein in oral squamous cell carcinoma cell by AICAR, as AMPK activated reagent were examined using a MTS assay and western blotting. As a result, dose-dependent and time-dependent suppressant effect of progression by AICAR was confirmed. Furthermore, time-dependent increase of AMPKα, Phospho-AMPKα, bax and p53 and time-dependent decrease of bcl-2 and PCNA were confirmed by western blotting. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討」課題番号20791503 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20791503/20791503seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30444201 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30444201 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791503/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791503/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20791503/20791503seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20791503/20791503seika/ |