WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "dd4e7783-4b6b-43ed-92b6-fcf8d757094c"}, "_deposit": {"created_by": 18, "id": "46885", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "46885"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00046885", "sets": ["2840"]}, "author_link": ["81641", "81640"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "3p.", "bibliographicVolumeNumber": "1992-1993", "bibliographic_titles": [{"bibliographic_title": "平成5(1993)年度 科学研究費補助金 一般研究(B) 研究成果報告書"}, {"bibliographic_title": "1993 Fiscal Year Final Research Report", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujii, Tozo"}], "nameIdentifiers": [{"nameIdentifier": "81641", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20019649", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20019649"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "1.2-Hydroxy-1\u0027-methylzeatin(I)の両対掌体を合成するために,D-及びL-alanineから出発して[R-(E)]-及び[S-(E)]-4-amino-2-methyl-2-penten-1-ol ethanedioate[(R)-II及び(S)-II]を合成した.Et_3Nの存在下2-hydroxy-6-methylthiopurineに(R)-II及び(S)-IIをそれぞれ反応させることで(1\u0027R)-I及び(1\u0027S)-Iが好収率で得られた.各種スペクトルの比較から,緑藻から単離された新規サイトカイニンはIの構造を有することが判明し,また,サイトカイニン活性の比較によって,天然品は(1\u0027R)-Iの絶対構造を有することが推定された.\n2.D-及びL-alanineから[R-(Z)]-及び[S-(Z)]-4-amino-2-methyl-2-penten-1-ol ethanedioate[(R)-III及び(S)-III]を合成し,これらと6-chloropurineあるいはその9-ribosyl体と反応させることで,(1\u0027R)-及び(1\u0027S)-1\u0027-methyl-cis-zeatin[(1\u0027R)-IV及び(1\u0027S)-IV]あるいはそれらの9-ribosyl体[(1\"R)-V及び(1\"S)-V]を合成した.\n3.上記合成法に類似した反応経路で,(1\u0027R)-及び(1\u0027S)-N^6-(1,3-dimethyl-2-butenyl)adenine[(1\u0027R)-VI及び(1\u0027S)-VI]やそれらの9-ribosyl体[(1\"R)-VII及び(1\"S)-VII]を合成した.\n4.cis-Zeatinの新規合成法として,「α-アミノアルデヒド/オレフィン化法」を開発した.この応用で9-(2-deoxy-β-D-ribofuranosyl)-cis-zeatin(VIII)を合成することができた.\n5.タバコ・カルス検定法及びレタス種子発芽検定法によって,上記の天然型関連新規サイトカイニン類[(1\u0027R)-I,(1\u0027S)-I,(1\u0027R)-IV,(1\u0027S)-IV,(1\"R)-V,(1\"S)-V,(1\u0027R)-VI,(1\u0027S)-VI,(1\"R)-VII,(1\"S)-VII,及びVIII]や既知の天然サイトカイニン類のサイトカイニン活性を調べ,構造-活性相関について興味ある知見を得ることができた.", "subitem_description_type": "Abstract"}, {"subitem_description": "1. The first chiral synthesis of 2-hydroxy-1\u0027-methyl-trans-zeatin (1)has been accomplished. The systhesis started from D-or L-alanine and proceeded through an alpha-amino aldehyde/olefination route to give[R-(E)]-or[S-(E)]-4-amino-2-methyl-2-penten-1-ol ethanedioate [(R)-2 or (S)-2]. Condensations of 2-hydroxy-6methylthiopurine with (R)-2 and (S)-2 furnishied (1\u0027R)-1 and (1\u0027S)-1, respectively. As a result or this synthesis, the gross structure of a marine green alga cytokinin was established to be 1.\n2. In a similar manner, [R-(Z)]-and [S-(Z)]-4-amino-2-methyl-2-penten-1-ol ethanedioates [(R)-3 and (S)-3] were prepared from D- and L-alanine, respectively. Condensations of (R)-3 and (S)-3 with 6-chloropurine or its 9-riboside gave (1\u0027R)-and (1\u0027S)-1\u0027-methyl-cis-zeatins [(1\u0027R)-4 and (1\u0027S)-4] or their 9-ribosides [(1\"R)-5 and (1\"S)-5].\n3. Both enantiomers [(1\u0027R)-6 and (1\u0027S)-6] of N^6-(1,3-dimethyl-2-butenyl)adenine (6) and their 9-ribosides [(1\"R)-7 and (1\"S)-7] were synthesized via analogous routes.\n4. A novel synthesis of cis-zeatin was achieved through an alpha-amino aldehyde/olefination route, which was also applied successfully to the synthesis of 9-(2-deoxy-beta-D-ribofuranosyl)-cis-zeatin(8).\n5. The above 1\u0027-or 1\"-methylated derivatives [(1\u0027R)-1, (1\u0027S)-1, (1\u0027R)-4, (1\u0027S)-4, (1\"R)-5, (1\"S)-5, (1\u0027R)-6, (1\u0027S)-6, (1\"R)-7. (1\"S)-7. amd 8] of the zeatin and IPA families were tested for cytokinin activity in the tobacco callus and the lettuce seed germination bioassays to discuss their structure-activity relationships.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:04453152, 研究期間(年度):1992-1993", "subitem_description_type": "Other"}, {"subitem_description": "出典:「天然型関連新規サイトカイニン類の合成と植物ホルモン作用」研究成果報告書 課題番号04453152\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所))\n 本文データは著者版報告書より作成", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00053212", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_17": {"attribute_name": "公開者", "attribute_value_mlt": [{"subitem_publisher": "金沢大学薬学部"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/search/?qm=20019649"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=20019649", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04453152/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04453152/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-04453152/044531521993kenkyu_seika_hokoku_gaiyo/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-04453152/044531521993kenkyu_seika_hokoku_gaiyo/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "藤井, 澄三"}], "nameIdentifiers": [{"nameIdentifier": "81640", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20019649", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20019649"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-02-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-FUJII-T-kaken 1994-3p.pdf", "filesize": [{"value": "41.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 41900.0, "url": {"label": "PH-PR-FUJII-T-kaken 1994-3p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/46885/files/PH-PR-FUJII-T-kaken 1994-3p.pdf"}, "version_id": "51766cd2-1083-4346-8e80-c2ae2df43812"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "サイトカイニン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "植物ホルモン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ゼアチン誘導体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IPA誘導体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "α-アミノアルデヒド", "subitem_subject_scheme": "Other"}, {"subitem_subject": "プリニル化", "subitem_subject_scheme": "Other"}, {"subitem_subject": "タバコ・カルス検定法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "レタス種子発芽検定法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cytokinin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Phytohormone", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Zeatin derivative", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IPA derivative", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "alpha-Amino aldehyde", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Purinylation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tobacco callus bioassay", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lettuce seed germination bioassay", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "天然型関連新規サイトカイニン類の合成と植物ホルモン作用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "天然型関連新規サイトカイニン類の合成と植物ホルモン作用"}, {"subitem_title": "Syntheses and Cytokinin Activities of the 1\u0027-or 1\"-Methyl Derivatives in the Zeatin and IPA Families", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "18", "path": ["2840"], "permalink_uri": "https://doi.org/10.24517/00053212", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-02-14"}, "publish_date": "2019-02-14", "publish_status": "0", "recid": "46885", "relation": {}, "relation_version_is_last": true, "title": ["天然型関連新規サイトカイニン類の合成と植物ホルモン作用"], "weko_shared_id": -1}
天然型関連新規サイトカイニン類の合成と植物ホルモン作用
https://doi.org/10.24517/00053212
https://doi.org/10.24517/00053212e22cba51-9671-4d11-b8f1-c47b45c3309a
名前 / ファイル | ライセンス | アクション |
---|---|---|
PH-PR-FUJII-T-kaken 1994-3p.pdf (41.9 kB)
|
Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-02-14 | |||||
タイトル | ||||||
タイトル | 天然型関連新規サイトカイニン類の合成と植物ホルモン作用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Syntheses and Cytokinin Activities of the 1'-or 1"-Methyl Derivatives in the Zeatin and IPA Families | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053212 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Fujii, Tozo
× Fujii, Tozo |
|||||
書誌情報 |
平成5(1993)年度 科学研究費補助金 一般研究(B) 研究成果報告書 en : 1993 Fiscal Year Final Research Report 巻 1992-1993, p. 3p., 発行日 1994-03 |
|||||
出版者 | ||||||
出版者 | 金沢大学薬学部 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 1.2-Hydroxy-1'-methylzeatin(I)の両対掌体を合成するために,D-及びL-alanineから出発して[R-(E)]-及び[S-(E)]-4-amino-2-methyl-2-penten-1-ol ethanedioate[(R)-II及び(S)-II]を合成した.Et_3Nの存在下2-hydroxy-6-methylthiopurineに(R)-II及び(S)-IIをそれぞれ反応させることで(1'R)-I及び(1'S)-Iが好収率で得られた.各種スペクトルの比較から,緑藻から単離された新規サイトカイニンはIの構造を有することが判明し,また,サイトカイニン活性の比較によって,天然品は(1'R)-Iの絶対構造を有することが推定された. 2.D-及びL-alanineから[R-(Z)]-及び[S-(Z)]-4-amino-2-methyl-2-penten-1-ol ethanedioate[(R)-III及び(S)-III]を合成し,これらと6-chloropurineあるいはその9-ribosyl体と反応させることで,(1'R)-及び(1'S)-1'-methyl-cis-zeatin[(1'R)-IV及び(1'S)-IV]あるいはそれらの9-ribosyl体[(1"R)-V及び(1"S)-V]を合成した. 3.上記合成法に類似した反応経路で,(1'R)-及び(1'S)-N^6-(1,3-dimethyl-2-butenyl)adenine[(1'R)-VI及び(1'S)-VI]やそれらの9-ribosyl体[(1"R)-VII及び(1"S)-VII]を合成した. 4.cis-Zeatinの新規合成法として,「α-アミノアルデヒド/オレフィン化法」を開発した.この応用で9-(2-deoxy-β-D-ribofuranosyl)-cis-zeatin(VIII)を合成することができた. 5.タバコ・カルス検定法及びレタス種子発芽検定法によって,上記の天然型関連新規サイトカイニン類[(1'R)-I,(1'S)-I,(1'R)-IV,(1'S)-IV,(1"R)-V,(1"S)-V,(1'R)-VI,(1'S)-VI,(1"R)-VII,(1"S)-VII,及びVIII]や既知の天然サイトカイニン類のサイトカイニン活性を調べ,構造-活性相関について興味ある知見を得ることができた. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 1. The first chiral synthesis of 2-hydroxy-1'-methyl-trans-zeatin (1)has been accomplished. The systhesis started from D-or L-alanine and proceeded through an alpha-amino aldehyde/olefination route to give[R-(E)]-or[S-(E)]-4-amino-2-methyl-2-penten-1-ol ethanedioate [(R)-2 or (S)-2]. Condensations of 2-hydroxy-6methylthiopurine with (R)-2 and (S)-2 furnishied (1'R)-1 and (1'S)-1, respectively. As a result or this synthesis, the gross structure of a marine green alga cytokinin was established to be 1. 2. In a similar manner, [R-(Z)]-and [S-(Z)]-4-amino-2-methyl-2-penten-1-ol ethanedioates [(R)-3 and (S)-3] were prepared from D- and L-alanine, respectively. Condensations of (R)-3 and (S)-3 with 6-chloropurine or its 9-riboside gave (1'R)-and (1'S)-1'-methyl-cis-zeatins [(1'R)-4 and (1'S)-4] or their 9-ribosides [(1"R)-5 and (1"S)-5]. 3. Both enantiomers [(1'R)-6 and (1'S)-6] of N^6-(1,3-dimethyl-2-butenyl)adenine (6) and their 9-ribosides [(1"R)-7 and (1"S)-7] were synthesized via analogous routes. 4. A novel synthesis of cis-zeatin was achieved through an alpha-amino aldehyde/olefination route, which was also applied successfully to the synthesis of 9-(2-deoxy-beta-D-ribofuranosyl)-cis-zeatin(8). 5. The above 1'-or 1"-methylated derivatives [(1'R)-1, (1'S)-1, (1'R)-4, (1'S)-4, (1"R)-5, (1"S)-5, (1'R)-6, (1'S)-6, (1"R)-7. (1"S)-7. amd 8] of the zeatin and IPA families were tested for cytokinin activity in the tobacco callus and the lettuce seed germination bioassays to discuss their structure-activity relationships. |
|||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:04453152, 研究期間(年度):1992-1993 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「天然型関連新規サイトカイニン類の合成と植物ホルモン作用」研究成果報告書 課題番号04453152 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) 本文データは著者版報告書より作成 |
|||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=20019649 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=20019649 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04453152/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04453152/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-04453152/044531521993kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-04453152/044531521993kenkyu_seika_hokoku_gaiyo/ |